Research progress in biomarkers of diabetic macular edema on optical coherence tomography

Authors: Jiang Jingwen,  Chen Changzheng

DOI: 10.3760/cma.j.cn115989-20190617-00264
Published 2021-01-10
Cite as Chin J Exp Ophthalmol, 2021,39(01): 89-92.

Abstract                               [View PDF] [Read Full Text]

Diabetic retinopathy (DR) is a common ocular complication in patients with diabetes, and diabetic macular edema (DME) is the main cause of vision loss in patients with DR, so the early diagnosis and treatment of DME is of an important clinical significance.Optical coherence tomography (OCT) can provide high-quality imaging of retina and choroid.It has been widely used in clinical practice and can be used for long-term follow-up of the diagnosis and treatment of DME.Recent studies have found various characteristic changes in retina and choroidal layer of DME on OCT, including vitreomacular interface abnormalities, disorganization of retinal inner layers, inner segment-outer segment (IS-OS) continuity destruction, external limiting membrane continuity destruction, outer retinal tubulations, hyperreflective foci, intraretinal cystic fluid, subfoveal neuroretinal detachment, low optical reflectivity, subfoveal choroidal thickness change, and choroidal vascularity index change, etc.These changes are related to the prognosis of DME, so they can be used as biomarkers of DME.This paper reviews the research progress in this field.

Key words:

Optical coherence tomography; Diabetic macular edema; Biomarkers; Diabetic retinopathy; Review

Contributor Information

Jiang Jingwen
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
Chen Changzheng
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
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