Research progress of diabetic keratopathy

With the increase of diabetes mellitus, the incidence of diabetic complications has gradually attracted the attention of researchers.Long-term hyperglycemia has toxic effects on cells and tissues in the body, and its most profound effects on eye tissue are the cornea and retina.Clinicians begin to focus on diabetic keratopathy since the occurrence of corneal epithelial lesions after vitrectomy in diabetic patients, and find that hyperglycemia causes damage of different degrees to each layer of the corneal structure by changing the corneal morphology, metabolism and physiology, including corneal epithelium, corneal nerves, tear film and endothelium.Diabetes mellitus results in clinical abnormalities that are referred to as diabetic keratopathy.This review mainly focused on the pathogenesis, clinical features and treatment of diabetic keratopathy.