Research progress of mesenchymal stem cells for the treatment of diabetic retinopathy

Authors:Chen Li,  Chen Song
DOI: 10.3760/cma.j.issn.2095-0160.2016.07.020
Published 2016-07-10
Cite as Chin J Exp Ophthalmol, 2016,34(7): 667-671.

Abstract

Diabetic retinopathy (DR) is one of the major complications of diabetes.It includes microvascular disease and neuronal function change.For the early treatment of DR, there are a variety of drugs and biologic preparations, including mesenchymal stem cells (MSCs). As a kind of tissue engineering cell, it has broad prospects and gradually receives increasing attention.MSCs have strong ability of multi-directional differentiation and immune-regulation.Treating DR by MSCs may have a variety of mechanisms.Anti-inflammatory and neuroprotective effects of DR have been confirmed.According to the studies of MSCs in vitro and in vivo experiments.The researchers found that different MSCs transplantation approaches can improve retinal function in early DR and delay the development of DR.This paper was to a review on the research progress.

Key words:

Diabetic retinopathy; Mesenchymal stem cells; Transplantation pathway; Treatment; Review

Contributor Information

Chen Li
Tianjin Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical university, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Institute of Ophthalmology, Tianjin 300020, China
Chen Song
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Updated: October 8, 2019 — 9:05 am