Role of mitochondria in the optic neuropathy

Authors: Ji Kaibao,  Zhang Xu
DOI: 10.3760/cma.j.issn.2095-0160.2016.07.019
Published 2016-07-10
Cite as Chin J Exp Ophthalmol, 2016,34(7): 663-666.

Abstract                            [Download PDF] [Read Full Text]

Mitochondria are an important eukaryotic cell organelle with inner and outer membranes.They generate the necessary lifecycle energy for cells through aerobic respiration, and plays a role in oxidative stress and cell apoptosis in human body.Mitochondria have their own genetic material and genetic system.In more active structures, such as the retina and the optic nerve, mitochondria are more abundant, providing the necessary energy for visual signaling and intracellular transport of substances.An increasing number of studies have shown that mitochondrial dysfunction is involved in optic nerve degeneration and affects retinal ganglion cell survival.This paper summarized the current research on the distribution and the role of mitochondria in the optic nerve and retinal ganglion cells.

Key words:

Mitochondria; Optic neuropathy; Retinal ganglion cell

Contributor Information

Ji Kaibao
Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology & Visual Sciences, Key Laboratory of Ophthalmology of Jiangxi Province, Nanchang 330006, China
Zhang Xu
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