Research progress on pachychoroid disease

Authors: Yin Xinkai,  Dai Rongping

DOI: 10.3760/cma.j.cn115989-20200706-00478
Published 2021-01-10
Cite as Chin J Exp Ophthalmol, 2021,39(01): 78-83.

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Abstract

Pachychoroid disease is a relatively novel concept proposed in ophthalmology in recent years, which describes a series of pathological conditions including chronic persistent choroidal thickening and choroidal vasodilatation, with choroid blood capillary layer capacity attenuation, choroidal vasodilation, focal or disseminated choroidal thickening, progressive retinal pigment epithelial dysfunction and choroid retinal neovascularization as characteristic symptoms.Nowadays, the definition of pachychoroid disease has gradually changed from the previous emphasis on the simple thickening of choroid to the morphological description of complex pathological conditions.The clinical manifestations of certain pachychoroid diseases have been clearly described including central serous chorioretinopathy (CSC), pachychoroid neovasculcularization (PNV), polypoid choroidal vasculopathy (PCV), focal choroidal excavation (FCE), peripapillary pachychoroid syndrome (PPS). These entities have certain characteristic choroidal vasculopathy, which may represent different clinical manifestations of the same type of pachychoroid diseaseor indicate that they have similarpathogenesis .In this article, the existing literature and recent findings about pachychoroid disease, as well as the classification and treatment of pachychoroid diseases spectrum were summarized and discussed.

Key words:

Pachychoroid disease; Characteristic; Review

Contributor Information

Yin Xinkai
Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Dai Rongping
Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
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Updated: January 26, 2021 — 9:36 am