Application of proteomics in age-related macular degeneration

Authors: Yang Fan,  Sun Xiaodong

DOI: 10.3760/cma.j.cn115989-2019-0105-00006
Published 2021-01-10
Cite as Chin J Exp Ophthalmol, 2021,39(01): 72-77.

Abstract

Age-related macular degeneration (AMD) is the mainirreversible blinding eye disease in the elderly.Its main pathogenic factors include age, genetic variation and lifestyle, but the specific pathogenesis has not been fully elucidated.As an emerging research method, proteomics technology has been gradually applied in the field of ophthalmology in recent years.A large number of studies about proteomic analysis of blood, tears, aqueous humor, vitreous humor, retina and choroid, drusen and RPE cell samples from AMD patients have been carried out to screen AMD biomarkers and explore the mechanism of AMD.These results can not only help us to make a more accurate diagnosis of AMD, but also play a guiding role in the selection of treatment targets and prognosis.

Key words:

Proteomics; Age-related macular degeneration; Biomarkers

Contributor Information

Yang Fan
Department of Ophthalmology, Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China
Sun Xiaodong
Department of Ophthalmology, Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China
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Updated: January 26, 2021 — 4:01 am