Research progress on risk factors of keratoconus

Authors: Xu Liyan,  Yang Kaili,  Ren Shengwei

DOI: 10.3760/cma.j.cn115989-20190131-00041
Published 2020-06-10
Cite as Chin J Exp Ophthalmol, 2020,38(06): 543-547.

Abstract

Keratoconus is a corneal ectasia disease characterized by conical protrusion, progressive corneal thinning and irregular astigmatism.The etiology of keratoconus remains unclear now.Multiple factors contribute to the disease.A large number of studies have shown that the occurrence of keratoconus is closely related to heredity, and there exists obvious genetic heterogeneity.The incidence of keratoconus in patients with allergic diseases and frequent eye rubbing is high.Ultraviolet irradiation can damage the ocular surface and induce keratoconus subsequently.Keratectasia is a serious complication after refractive surgery.In this article, the risk factors including genetic susceptibility, eye rubbing, allergic diseases, ultraviolet irradiation, refractive surgery that related to keratoconus are reviewed.

Key words:

Keratoconus; Risk factors; Genetic susceptibility

Contributor Information

Xu Liyan
Department of Ophthamology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
Yang Kaili
Department of Ophthamology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
Ren Shengwei
Department of Ophthamology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
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Updated: July 2, 2020 — 1:28 am