Association between MeCP2 and proliferative vitreoretinopathy under the regulation of tumor necrosis factor

Authors: Xu Yuejuan,  Li Xiaohua

DOI: 10.3760/cma.j.cn115989-20191111-00491
Published 2020-06-10
Cite as Chin J Exp Ophthalmol, 2020,38(06): 548-552.

Abstract

Proliferative vitreoretinopathy (PVR) is an ocular fundus disease involving multiple cytokines.Its important pathological process is epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells.Tumor necrosis factor (TNF) is an important inflammatory response inducing factor, which can be produced by activated RPE cells, microglia, monocytes and macrophages, and then participate in the occurrence and development of PVR.In addition to cytokines, epigenetic factors such as DNA methylation also play an important role in the development of PVR, in which methyl-CpG binding protein 2(MeCP2) is involved in EMT and fibrosis, and is highly expressed in PVR membrane.The positive expression of MeCP2 is also found in transformed RPE cells and microglia.It is speculated that MeCP2 plays an important role in the occurrence and development of PVR.TNF can also stimulate the expression of MeCP2.This article reviews the role of MeCP2 and the interaction between TNF and MeCP2 in the formation of PVR.

Key words:

Tumor necrosis factor; MeCP2; DNA methylation; Proliferative vitreoretinopathy; Epigenetics

Contributor Information

Xu Yuejuan
Department of Ophthalmology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, Henan University People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou 450003, China
Li Xiaohua
Department of Ophthalmology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, Henan University People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou 450003, China
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