Research progress on single nucleotide polymorphisms of genes associated with diabetic retinopathy

Authors: Han Junlin,  Han Mei
DOI: 10.3760/cma.j.issn.2095-0160.2019.05.014
Published 2019-05-10
Cite as Chin J Exp Ophthalmol, 2019,37(5): 390-395.
Abstract

Diabetic retinopathy (DR) is the common cause of irreversible vision loss in adults during working age, accounting for 4.8% of global blindness.With the progress of disease, most patients with diabetes mellitus will eventually lead to DR.Epidemiological studies have shown that the severity of DR is closely related to blood glucose levels and duration of diabetes, but there is growing evidence that genetic factors play an important role in the development and progression of DR.As the relationship between genetic polymorphism and DR constantly deepen, dozens of DR-related genes and genetic variations have been screened out from the PubMed Network Human Mendel Genetics Online till March 1, 2018, including vascular endothelial growth factor, aldose reductase, receptor for advanced glycation end products, mitochondrial thioredoxin antioxidant system, monocyte chemoattractant protein-1, interleukin (IL)-6, IL-8 and other genes, some genetic polymorphisms have been identified as a genetic risk factor for DR in diabetic patients.The progress of genetic polymorphisms closely related to DR was summarized.

Key words: Diabetic retinopathy; Gene; Single nucleotide polymorphism; Type 2 diabetes

Contributor Information

Han Junlin
Clinical College of Ophthalmology Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin 300020, China
Han Mei
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Updated: October 16, 2019 — 11:30 am