Research progress on the role of Cx36 in retinal signal transduction and myopia progression

Authors: Zhang Hao, Guo Junguo, Bi Hongsheng
   

Citation

Zhang Hao, Guo Junguo, Bi Hongsheng. Research progress on the role of Cx36 in retinal signal transduction and myopia progression[J]. Chin J Exp Ophthalmol, 2025, 43(2):169-173. DOI: 10.3760/cma.j.cn115989-20220921-00440.

ABSTRACT                     [Download PDF] [Read Full Text]

The retina is a crucial site for mediating the conversion of external light signals into neural electrical signals.Connexin (Cx), as the basic structural and functional protein molecule of gap junction channels, plays an important role in maintaining the functional homeostasis of the retina.Cx36 has physiological functions in aspects such as retinal information transmission and biochemical factor regulation, and is involved in the formation of myopia.The ” local retina-sclera remodeling” theory holds that abnormal visual information acts on the retina, causing sclera remodeling through retinal pigment epithelium-choroid signal transduction, and ultimately leading to myopia.Exploring the role and mechanism of retinal Cx36 in visual development and myopia formation is of great guiding significance for myopia prevention and control.This article reviews the research progress in the physiological functions of Cx36 in the retina and its role in myopia development in recent years.

Retina;Connexin 36;Myopia;Signal transduction

Authors Info & Affiliations

Zhang Hao
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, China
Guo Junguo
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, China
Bi Hongsheng
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, China
Shandong Academy of Eye Disease Prevention and Therapy, Jinan 250002, China
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