Research progression of Fractalkine/cx3cr1 and microglia in retina diseases

Authors: Li Juanjuan,  Li Yan
DOI: 10.3760/cma.j.issn.2095-0160.2015.09.021
Published 2015-09-10
Cite as Chin J Exp Ophthalmol, 2015,33(9): 861-864.

Abstract                              [Download PDF] [Read Full Text]

Fractalkine (Fkn) is the only member of CX3C subfamily of chemokine currently found, cx3cr1 is its specific receptor. Fkn/cx3cr1 is involved in inflammation, cancer, autoimmune diseases, allergy, acquired immune deficiency syndrome and other diseases, while its variety of pathophysiological role is accomplished by microglia. Functions of Fkn/cx3cr1 and microglia in age-related macular degeneration, acute light damage disease, retinal vascular disease, diabetic retinopathy disease, uveitis and other retina disease were reviewed in this article.

Key words:

Fractalkine; Cx3cr1; Microglia; Retina

Contributor Information

Li Juanjuan
Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, China
Li Yan
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Updated: March 23, 2023 — 2:06 am