Current researches of tissue engineering corneal epithelium seed cells

Authors: Cao Jingjie,  Zhang Chen,  Zhao Shaozhen
DOI: 10.3760/cma.j.issn.2095-0160.2015.09.020
Published 2015-09-10
Cite as Chin J Exp Ophthalmol, 2015,33(9): 857-860.

Abstract                            [Download PDF] [Read Full Text]

Keratoplasty is a choice for the treatment of ocular surface diseases caused by corneal limbal stem cells (LSCs) deficiency. The application of traditional keratoplasty is limited by avaibility of donor corneas and allograft rejection. Constructruction of tissue engineering corneal epithelium provides an important and effective approach to the transplantation of cornea, because it can solve the lack of donor corneas and avoid allograft rejection following keratoplasty. However, the selection of the seed cells is crucial to corneal tissue engineering. What is more, the research of seed cells is becoming more and more widespread, just like embryonic stem cells (ESCs) and LSCs. This article summarized the selection of seed cells and the progress of tissue-engineered human corneal epithelium.

Key words:

Epithelium, corneal/transplantation; Tissue engineering/methods; Stem cells/cytology; Cell differentiation; Cells, cultured; Tissue engineering corneal epithelium

Contributor Information

Cao Jingjie
Department of Refraction and Corneal, Tianjin Medical University Eye Hospital & Eye Institute, Tianjin 300384, China
Zhang Chen
Zhao Shaozhen
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Updated: March 23, 2023 — 2:07 am