Research status of blepharokeratoconjunctivitis

Blepharokeratoconjunctivitis (BKC) is a chronic inflammatory disorder and can be defined as lid margin blepharitis accompanied by conjunctivitis and keratopathy.Typical clinical characteristics of BKC consisted of conjunctival hyperemia, papillary hyperplasia follicles, punctate keratitis, marginal keratitis, corneal punctuate epithelial erosion, corneal ulcer, corneal scar and vascularization, corneal perforation.The clinical symptoms and signs of BKC are complicated, which can lead to misdiagnose.The physiotherapy of BKC includes eyelid hygiene, meibomian glands massage and warm compresses; the drug treatment of BKC includes artificial tear, topical antibiotics, corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), immunosuppressants and so on.Corneal transplantation is required for the severe BKC patients.The etiology, pathogenesis, diagnosis and management of BKC was reviewed in this artcle.