Review and analysis on knockout mouse models with cataract

Authors: Wu Zehua,  Liu Xiangyuan,  Li Yuying,  Zhong Zilin,  Chen Jianjun

DOI: 10.3760/cma.j.cn115989-20190227-00087
Published 2020-08-10
Cite as Chin J Exp Ophthalmol, 2020,38(08): 710-714.

Abstract

Cataract is the leading cause of blindness worldwide, which is a generally clinical and genetic heterogeneity eye disease.To date, more than 50 genes have been reported to be associated with congenital cataract.While for mouse, parts of human cataract related genes knockout mouse can also resulted cataract.As we know, the model of cataract related gene knockout mice can help us to understand the phenotype, pathogenesis, progress and prognosis of human cataract and it can also help to find unknow genes that not reported in human cataract yet.In this review, knockout mouse models with cataract are summarized, which can help to facilitate identification of cataract genes and clarification of the mechanisms of cataractgenisis.

Key words:

Cataract; Mouse model; Gene; Knockout

Contributor Information

Wu Zehua
Translation Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200081, China
Liu Xiangyuan
Department of Ophthamology, Shanghai Tenth People’s Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai 200072, China
Li Yuying
Department of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China
Zhong Zilin
Department of Ophthamology, Shanghai Tenth People’s Hospital, Tongji Eye Institute, Tongji University School of Medicine, Shanghai 200072, China
Chen Jianjun
Translation Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200081, China
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Updated: August 19, 2020 — 8:36 am