Category: 2020, No. 08

Gene therapy for retinal diseases: global progress and challenges

Authors: Wu Zhijian DOI: 10.3760/cma.j.cn115989-20200716-00500 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 633-638. Abstract In the past three decades, we have witnessed the great promise of gene therapy in treating a variety of inherited and acquired retinal diseases. The large number of preclinical studies in retinal gene therapy has led to over sixty clinical […]

Effects of miR-338-3p/TCF4 on choroidal microvascular endothelial cell proliferation and apoptosis

Authors: Li Jiancheng,  Bu Zhanyun,  Pan Junhui DOI: 10.3760/cma.j.cn115989-20200407-00242 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 639-645. Abstract Objective To investigate whether microRNA-338-3p (miR-338-3p) affects the proliferation and apoptosis of choroidal microvascular endothelial cells by regulating the expression of T cell factor 4 (TCF4). Methods Human choroidal microvascular endothelial cells were cultured in vitro, and […]

Differential gene expression profiles of trabecular meshwork between POAG and non-POAG donated eyes by using RNA-sequencing

Authors: Liu Lifang,  Zeng Jinhui,  Huang Chukai,  Wang Geng,  Zhang Mingzhi DOI: 10.3760/cma.j.cn115989-20191018-00451 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 646-652. Abstract Objective To investigate gene basis of primary open angle glaucoma (POAG) by comparing gene expression profile of trabecular meshwork between POAG patients and normal controls by using RNA-sequencing. Methods Trabecular meshwork specimen […]

In vitro interactions between antifungals and tacrolimus against Fusarium solani

Authors: Chen Xiaolian,  Ding Hui,  Liu Hongshan,  He Hong,  Wu Jiaochan,  Hu Xianlyu,  Zhong Xingwu DOI: 10.3760/cma.j.cn115989-20190613-00260 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 653-658. Abstract Objective To investigate the in vitro interaction between antifungals and tacrolimus against Fusarium solani. Methods According to Clinical and Laboratory Standards Institute(CLSI) M27-Ed4 and M38-A3, 24 strains of Fusarium solani isolated from clinic […]

Association of TLR4 polymorphisms with primary open angle glaucoma in Chinese population

Authors: Shu Yi,  Xu Jiaxin,  Yang Chen,  Chen Yilian,  Luo Qian,  Gong Bo,  Yang Zhenglin,  Huang Guo DOI: 10.3760/cma.j.cn115989-20191120-00505 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 659-664. Abstract Objective To detect whether Toll-like receptor 4 (TLR4) polymorphisms contributed to primary open angle glaucoma (POAG) in a Chinese population. Methods A Chinese cohort, including 799 […]

Association study of single nucleotide polymorphism of rs284489 in the 8q22 region with primary open angle glaucoma in a Sichuan Han Chinese population

Authors: Xu Siyao,  Liu Xiaoqi,  Lin Ying,  Gong Bo,  Yang Zhenglin DOI: 10.3760/cma.j.cn115989-20200509-00321 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 665-669. Abstract Objective To investigate the association between rs284489 in the 8q22 region and primary open angle glaucoma (POAG) in Sichuan, and the association between rs284489 and gender difference. Methods A case control study […]

TTR mutations and clinical characteristics of vitreous amyloidosis patients

Authors: Zhang Xiaohui,  Xu Ke,  Xu Xiaolin,  Xie Yue,  Li Yang DOI: 10.3760/cma.j.cn115989-20190419-00192 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 670-674. Abstract Objective To investigate the transthyretin (TTR) mutations and clinical characteristics of patients with vitreous amyloidosis. Methods Ten cases of suspected vitreous amyloidosis were recruited in Beijing Tongren Hospital from January 2011 to […]

Genotype and clinical phenotype analysis of a five-generation Ningxia family with autosomal dominant retinitis pigmentosa pedigree

Authors: Rong Weining,  Zhang Fangxia,  Liu Yani,  Lei Bo,  Sheng Xunlun DOI: 10.3760/cma.j.cn115989-20190212-00050 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 675-679. Abstract Objective To identify the pathogenic mutation in a five-generation Ningxia family with autosomal dominant retinitis pigmentsoa (adRP) and to analyze its associated clinical phenotype. Methods One adRP pedigree was recruited for this […]

Effect of VEGF-A gene mutation on neovascular age-related macular degeneration and the response to ranibizumab

Authors: Song Shuang,  Yang Fan,  Gu Xiaoya,  Zhang Peng,  Yu Xiaobing,  Dai Hong DOI: 10.3760/cma.j.cn115989-20200509-00320 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 680-685. Abstract Objective To investigate the effect of vascular endothelial growth factor-A (VEGF–A) gene mutation to neovascular age-related macular degeneration (nAMD) and the response to ranibizumab with this mutation in Chinese. Methods […]

Clinical evaluation of outcome of amniotic membrane transplantation combine with interferon eye drops for primary pterygium

Authors: Yu Jing,  Feng Jun,  Jie Ying,  Jin Tao,  Li Siyuan,  Zhu Lei DOI: 10.3760/cma.j.cn115989-20191217-00545 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 686-691. Abstract Objective To observe the clinical effect of the biological amniotic membrane transplantation combined with interferon α2b eye drops (interferon eye drops) in the treatment of primary pterygium. Methods A randomized […]