Roles of dendritic cells in the occurrence and development of diabetic keratopathy

Authors: Zhang Yuan,  Zhou Qingjun,  Xie Lixin
DOI: 10.3760/cma.j.cn115989-20190618-00267
Published 2021-03-10
Cite as Chin J Exp Ophthalmol, 2021, 39(3): 259-263.

Abstract

Diabetic keratopathy (DK) is a common ocular complication of diabetes.Long-term hyperglycemia impairs many structures of the cornea, leading to corneal opacity and visual dysfunction.A large number of researches focus on the epithelium and nerve abnormities in DK, but the pathogenesis is not completely elucidated.Dendritic cells (DCs) are specialized antigen-presenting cells, linking innate and adaptive immunity, participating in the occurrence and development of diabetes and its complications.To date, there are many myths in relationship between DCs and DK to be solved, and there are a few researches that investigate the relation between DCs and the occurrence and development of diabetes.In this article, the pathogenesis and pathogenic changes of DK, the types and functions of different DCs, the relationship between DCs and chronic inflammation and delayed healing of corneal epithelium in DK, as well as the role of DCs in corneal neuropathy were reviewed in order to provide some references for further investigations about the pathogenesis and treatment of DK.

Key words:

Dendritic cells; Diabetic keratopathy; Inflammation; Neurotrophic factors

Contributor Information

Zhang Yuan
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Zhou Qingjun
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China
Xie Lixin
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China
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Updated: March 16, 2021 — 6:58 am