Repair of dry eye-related corneal epithelial damage

Authors: Chen Junyu,  Pan Zhiqiang
DOI: 10.3760/cma.j.cn115989-20201102-00725
Published 2021-03-10
Cite as Chin J Exp Ophthalmol, 2021, 39(3): 264-268.

Abstract

Corneal epithelial injury refers to the destruction of corneal epithelial function and structural integrity caused by various reasons.Dry eye is a common cause of corneal epithelial damage and it also delays the healing of corneal epithelial wound.The change of tear film stability is a main mechanism of dry eye disease, which implies an important role of improving the tear film stability in dry eye and the repair of dry eye-related corneal epithelial damage.Ocular surface lubricants can be used to supplement the water-like liquid, mucin and lipid that tears naturally have.Anti-inflammatory drugs can improve the stability of tear film.When the ocular surface microenvironment is affected, the growth factors of the tear are unable to meet the needs of rapid repair of the damage.Therefore, it is necessary to supplement exogenous growth factor to promote injury healing of corneal epithelium.In this article, the repair of corneal epithelial damage associated with dry eye were reviewed, including the therapies of ocular surface lubricant, anti-inflammation and promoting repair of corneal epithelium.

Key words:

Dye eye; Corneal epithelial damage; Tear film stability

Contributor Information

Chen Junyu
Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Pan Zhiqiang
Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
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Updated: March 16, 2021 — 6:55 am