Signal pathways related to retinopathy of prematurity

Authors: Zhang Tongmei,  Han Mei
DOI: 10.3760/cma.j.issn.2095-0160.2015.07.021
Published 2015-07-10
Cite as Chin J Exp Ophthalmol, 2015,33(7): 664-668.

Abstract                              [Download PDF] [Read Full Text]

Retinopathy of prematurity (ROP) is a kind of vasoproliferative disorders, which leads to vision loss even blindness in premature neonates. Major pathogenesis in ROP is vascular occlusion and retinal neovascularization precipitated by ischemia and hypoxia. Proliferative retinopathy is asscioated with several signaling pathways, such as Wnt signaling pathway, CCN1/cysteine-rich 61(CCN1/Cry61) in pathological neovascularization, JAK/STAT (Janus kinase/signal transducer and activator of transcription) in intravitreous neovascularization, Apelin/APJ (Apelin/angiotensin type 1 receptor related protein) in pathological retinal angiogenesis. Deep understanding of the pathways is conducive to treat proliferative retinopathy by targeting pathologic neovessels.

Key words:

Retinopathy of prematurity; Hyperoxia; Retinal neovascularization; Signaling pathway

Contributor Information

Zhang Tongmei
Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, Tianjin 300020, China
Han Mei
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