Advances in etiology and pathogenesis of orbital lymphoma

Authors: Sun Mei,  Ma Jianmin
DOI: 10.3760/cma.j.cn115989-20191023-00463
Published 2022-11-10
Cite asChin J Exp Ophthalmol, 2022, 40(11): 1108-1113.

Abstract                               [View PDF] [Read Full Text]

Orbital lymphomas (OLs) are the common malignant tumor of the ocular adnexa.According to the source of abnormally proliferating lymphocytes, OLs can be further divided into several subtypes.The etiology and pathogenesis of OLs are still controversial.The current researches on OLs have shown that the etiology and pathogenesis of the disease are mainly related to genetic abnormalities of lymphocytes, abnormal immunosuppression, autoimmune diseases and chronic antigenic stimulation.However, there is no real lymphatic drainage system in the eye.Only a mucosa-associated lymphoid tissue (MALT) system extends from the lacrimal glands to the conjunctiva and lacrimal duct, so the pathogenesis of OLs is still unique.And the etiology of different OLs subtypes is quite different.For example, different chromosomal aberrations can cause varying subtypes of OLs, and various OLs subtypes have diverse predispositions in different autoimmune diseases.Researches on the etiology and pathogenesis of OLs at home and abroad were reviewed in this article to provide a reference for its clinical diagnosis and treatment.

Key words:

Orbit lymphoma; Cytogenetics; Immunity; Antigen

Contributor Information

Sun Mei

Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Beijing Ophthalmology &

Vision Science Key Lab, Beijing 100730, China

Ma Jianmin

Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Beijing Ophthalmology &

Vision Science Key Lab, Beijing 100730, China

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