Vitreous is a gelatinous, transparent, highly hydrated matrix that fills the posterior segment of eye.A diversity of proteins that can influence retinal physiology are present in vitreous.Moreover, the protein composition of vitreous alters in a number of vitreoretinal disease states.Therefore, analysis of protein composition in vitreous is an effective way to understand the pathophysiological mechanisms of vitreoretinal diseases and to discover biomarkers or treatment targets.Various proteomic methods have been gradually applied to the study of vitreous proteomics.Attempts aiming to establish a map of vitreous proteins for vitreoretinal diseases, such as diabetic retinopathy, epiretinal membranes, rhegmatogenous retinal detachment were performed over the last decade, some potential biomarkers have been discovered.This article reviewed the approaches of proteomics and advances in the study of vitreous proteomics of vitreoretinal diseases.
Authors:Song Minlu, Wang Fenghua
Cite as Chin J Exp Ophthalmol, 2019,37(9): 764-768.
Vitreous; Proteomics; Diabetic retinopathy; Epiretinal membrane; Retinal detachment
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China
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