Research progress of Cre/LoxP system in the eyes of animal model

Authors:Lou Xiangfeng,  Luo Xue,  Shen Yin
DOI: 10.3760/cma.j.issn.2095-0160.2019.09.015
Published 2019-09-10
Cite as Chin J Exp Ophthalmol, 2019,37(9): 759-763.

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Cre/LoxP system has been widely used as new type of gene targeting, which can transform genes in specific tissues and organs, remove specific gene fragments, and help to study the effects of specific genes on growth and development.Cre/LoxP system is the core technology of conditional gene targeting, which induces gene targeting, and spatiotemporal specific gene targeting.The resource about the mechanism of the Cre/LoxP system is helpful to obtain the Cre transgenic mouse model on different cell types of the retina.The Cre transgenic mice with specific expression in retinal bipolar cells and ganglion cells can provide the experimental basis for the absence of specific tissue single genes during growth and development.This review focused on the Cre/LoxP system and specific Cre recombinase mouse model in eyes.

Key words:

Mice, Cre transgenic; Disease model, mice; Retina

Contributor Information

Lou Xiangfeng
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
Luo Xue
Shen Yin
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