Aging and age-related macular degeneration

Authors: Lei Yi,  Yan Hua
DOI: 10.3760/cma.j.cn115989-20200602-00392
Published 2024-01-10
Cite as Chin J Exp Ophthalmol, 2024, 42(1): 76-79.

Abstract                             [Download PDF] [Read Full Text]

With the aging of the population in modern society, the incidence of age-related diseases increases gradually, especially the age-related macular degeneration (AMD). Despite advances in treatment in recent years, AMD remains one of the leading causes of blindness and visual impairment in the elderly.At present, people tend to think that AMD is caused by the combination of aging and inflammation, which also contribute to the occurrence and development of many other age-related diseases.Although more studies have focused on the role of inflammation in AMD, aging, as an important correlate, is also deserves in-depth investigation.This article reviewed the close relationship between substance accumulation, abnormal phagocytosis, abnormal mitochondrial function and oxidative stress damage caused by aging and the occurrence and development of AMD, with a view to improving clinicians’ knowledge of AMD.

Key words:

Aging; Age-related macular degeneration; Bruch membrane; Oxidative stress

Contributor Information

Lei Yi

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China

Yan Hua

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China

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