Anti-apoptotic mechanism of heme oxygenase 1 and its protective role in related ophthalmopathy

Authors: Chen Weiqi,  Hong Yu

DOI: 10.3760/cma.j.issn.2095-0160.2020.01.015
Published 2020-01-10
Cite as Chin J Exp Ophthalmol, 2020,38(01): 73-76.


Heme oxygenase 1 (HO-1) is a stress response protein, and its anti-apoptosis research becomes a new hot spot.In recent years, HO-1 plays an important protective role in ophthalmopathy.HO-1 is a rate-limiting enzyme of heme catabolism, which can catalyze the transformation of heme to bilirubin, carbon monoxide and free iron.HO-1 is the main effector molecule of anti-apoptosis.The biological characteristics and anti apoptosis mechanism of HO-1 were elaborated and the research progress of HO-1 in corneal diseases, glaucoma, cataract, uveitis, Graves ophthalmopathy, diabetic retinopathy, retinitis pigmentosa and related mechanisms, which were related to anti-apoptosis, were reviewed.

Key words:

Heme oxygenase 1; Apoptosis; Oxidative stress; Ophthalmopathy

Contributor Information

Chen Weiqi
Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
Hong Yu
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Updated: March 17, 2020 — 8:20 am