Category: 2020, No. 01

Changes of diagnosis and treatment strategies of retinal vein occlusion according to EURETINA updated guidelines

Authors: Dai Hong,  Lu Yingyi,  Xu Jingjing DOI: 10.3760/cma.j.issn.2095-0160.2020.01.001 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 1-3. Abstract Retinal vein occlusion (RVO) is one of the most common diseases severely threatening visual acuity.There is not a complete consensus on the clinical treatment strategies and schemes, and no guideline or consensus has been published in […]

Inhibitory effects of NADPH oxidase 4 inhibitor on VEGF expression in hypoxia-induced human RPE cells

Authors: Li Jing,  Yang Jing,  Kang Qianyan DOI: 10.3760/cma.j.issn.2095-0160.2020.01.002 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 4-9. Abstract Objective To observe the inhibitory effects of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) on vascular endothelial growth factor (VEGF) expression in hypoxia-induced human retinal pigment epithelial cells. Methods The cultured APRE-19 cells were divided into […]

Damage of blue-light exposure to retinal morphology and function in mice

Authors: Yang Daidi,  Sun Ruxu,  Chen Xue,  Liu Qinghuai DOI: 10.3760/cma.j.issn.2095-0160.2020.01.003 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 10-15. Abstract Objective To study the damage effects of blue-light exposure on retinal morphology and function in mouse. Methods Twenty 8-week-old clean C57BL/6J mice were randomly divided into blue-light exposure group and normal control group by […]

Antioxidative effect and mechanism of tert-butyl hydroquinone on rat retinal Müller cells under high glucose condition

Authors:He Wei,  Tian Min,  Yu Xi,  Cao Yang,  Zheng Wenli,  Lyu Hongbin DOI: 10.3760/cma.j.issn.2095-0160.2020.01.004 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 16-22. Abstract Objective To expore the impact of teniary butyl hydroquinone (tBHQ) on Müller cells in SD rats retina under high glucose condition, and discuss the mechanism of tBHQ. Methods The Müller cells […]

Protective effects of folic acid on retina in diabetic mice and its anti-oxidative stress mechanism

Authors: Li Yinglan,  Wu Min,  Xue Xiaoqin,  Li Changxing,  Lei Youfang,  Dai Dongfang DOI: 10.3760/cma.j.issn.2095-0160.2020.01.005 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 23-30. Abstract Objective To explore the protective effects of folic acid on retinas and its anti-oxidative stress mechanism in diabetic mice. Methods Thirty-two 16-week-old SPF degree male db/db mice were randomized into […]

Regulation and its mechanism of MeCP2 on biological behavior and epithelial-mesenchymal transition of LECs

Authors: Niu Chao,  Wu Zhong,  Huang Yalin,  Zhang Ying,  Wang Yingfei,  Li Xiaohua,  Lu Wenlong DOI: 10.3760/cma.j.issn.2095-0160.2020.01.007 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 32-37. Abstract Objective To investigate the role of methyl-CpG-binding protein 2 (MeCP2) in the regulation and epithelial-mesenchymal transition (EMT) of human lens epithelial cells (LECs) and its possible mechanism. Methods […]

Inhibitory effect of small interfering RNA-TLR9 on high glucose-induced retinal ganglion cell apoptosis

Authors: Yang Huihui,  Kan Quane,  Yu Lu,  Li Xuqing,  Huang Aiguo,  Yuan Huijuan DOI: 10.3760/cma.j.issn.2095-0160.2019.10.008 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 38-44. Abstract Objective To investigate the effect of Toll-like receptor 9 (TLR9) on high glucose-induced retinal ganglion cells-5 (RGC-5) apoptosis and the inhibitory effects of small interfering RNA-TLR9 (si-TLR9) on apoptosis. Methods […]

Unraveling the genetic cause of juvenile neuronal ceroid-lipofuscinosis

Authors: Shen Renjuan,  Zhou Rong,  Feng Zhuokun,  Wang Xiaofang,  Chen Chong,  Chen Zhenji,  Jin Zibing DOI: 10.3760/cma.j.issn.2095-0160.2020.01.009 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 45-49. Abstract Objective To analyze the clinical symptoms and hereditary information of suspicious juvenile neuronal ceroid-lipofuscinosis (JNCL) and determine the genotype in order to explore the diagnosis clues in the […]

Comparision of the clinical effects on vitrectomy with or without fovea-sparing internal limiting membrane peeling

Authors: Chen Xiuju,  Luo Xiangdong,  Sun Yaoyao,  Li Xiaoxin,  Zhang Chun DOI: 10.3760/cma.j.issn.2095-0160.2020.01.010 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 50-54. Abstract Objective To evaluate the clinical effects of vitrectomy with or without fovea-sparing internal limiting membrane peeling on macular foveoschisis (MF) secondary to pathologic myopia. Methods A non-randomized controlled study was adopted.Twenty-three patients […]

Spectral domain OCT for the differentiation of polypoidal choroidal vasculopathy from wet age-related macular degeneration

Authors: Xia Song,  Yang Jingyuan,  Zhao Xinyu,  Chen Youxin DOI: 10.3760/cma.j.issn.2095-0160.2020.01.011 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 55-59. Abstract Objective To evaluate the sensitivity and specificity of spectral domain optical coherence tomography (SD-OCT) for the differentiation of PCV from wet age-related macular degeneration (wAMD). Methods A cross-sectional study was conducted from Jun 2014 […]