Effects of complement dysfunction on diabetic retinopathy

Authors:Liao Yi,  Chen Hua

DOI: 10.3760/cma.j.issn.2095-0160.2020.01.014
Published 2020-01-10
Cite as Chin J Exp Ophthalmol, 2020,38(01): 68-72.

Abstract

Diabetic retinopathy (DR) is one of the common neuronal and microvascular complications of diabetes, and it is the key cause of blindness in the populations aged from 20 to 74.The pathogenesis of DR remains elusive, and the role of complement in DR has attracted intensive attentions in recent years.The dysregulation of complement factors and regulatory proteins could affect the fate and functions of pericytes, endothelial cells, neuronal cells and glia cells in retina, which may be novel targets for anti-DR therapy.Advances regarding the characteristics of complement in the eye, the relationship between complement dysfunction and DR, complement gene polymorphism in DR and recent therapy explorations targeting complement pathways were reviewed, so as to providing new clues for the related research in the future.

Key words:

Diabetic Retinopathy; Inflammation; Complement

Contributor Information

Liao Yi
Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen 361102, China
Chen Hua
School of Public Health, Fujian Medical University, Fuzhou 350108, China
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Updated: March 17, 2020 — 8:23 am