Applications of capsular bag model in posterior capsular opacification

Posterior capsular opacification (PCO), also known as after-cataract, is the most frequent complication and the primary cause for visual decrease after extracapsular cataract surgery.At present, there is no effective way to treat PCO, so more attentions are focused on preventive reseaching of PCO and treatment methods.Although a variety of studies have increased our understanding of the pathogenesis of PCO, the cellular mechanisms responsible for PCO are still unclear.Cultured capsular bag model in vitro could effectively simulate lens capsular membrane and cells survival environment after cataract extraction and IOL implantation.However, lens capsular bag cultivation with different methods have their own characreristics.The material source, preparation methods of capsular bag model, characreristics of materials which maintain capsular bag contours and its application in PCO were reviewed.