Category: 2016, No. 03

Enhencing awareness, identification and management of cataract surgery, improving comprehensive diagnosis and treatment ability of cataract

Authors: Xu Wen,  Li Shuyi DOI: 10.3760/cma.j.issn.2095-0160.2016.03.001 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 193-198. Abstract Cataract is still the main blinding eye disease, and it is a major goal of fighting blindness in China.In the past years, the diagnosis, treatment technology and equipment have made great progress.With the further understanding of this disease and […]

Construction of Smac siRNA lentiviral vector and its silencing effect on Smac gene in human LECs

Authors: Li Yun,  Zheng Guangying,  Jiang Yu DOI: 10.3760/cma.j.issn.2095-0160.2016.03.002 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 199-204. Abstract Background Research comfirmed that second mitochondrial activator of caspase (Smac) is a promoting tumor cell apoptosis protein.Our previous study showed that the expression level of Smac in LECs is obviously higher in cataract than that in normal eyes.We […]

Expression and its significance of aquaporin0 and 1 in lens with age-related cataract

Authors: Zhan Zhiyun,  Xu Guoxing,  Xie Maosong DOI: 10.3760/cma.j.issn.2095-0160.2016.03.003 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 205-209. Abstract Background Age-related cataract is a common cause of blindness.However, its cause and pathogenic mechanism have not been fully understood.Recent studies revealed that aquaporin 1 (AQP1) and AQP0 are closely related to the pathogenesis of cataract. Objective This study […]

In vitro epithelial-mesenchymal transition model for LECs of human posterior capsule opacification

Authors: Yang Baoxia,  Wang Ye,  Zhao Xiaowen,  Liu Ting,  Huang Yusen DOI: 10.3760/cma.j.issn.2095-0160.2016.03.004 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 210-217. Abstract Background Epithelial-mesenchymal transition (EMT) is one of the pathogenesis mechanisms of posterior capule opcification (PCO). Studying EMT is of important significance for the prevention and treatment of PCO.However, EMT model is lack. Objective This study was […]

The regulation of estradiol on growth dynamics of human LECs affected by increasing telomerase activity

Authors: Wang Jie,  Kang Gangjin,  Yuan Xuefeng,  Xu Manhua,  Jiang Yan,  Luo Bo DOI: 10.3760/cma.j.issn.2095-0160.2016.03.006 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 219-225. Abstract Background Human LECs can express telomerase activity, which participates in the formation of cataract.It is reported that estrogen can increase the expression of telomerase activity in human endometrial cancer and breast cancer cells and play […]

Anti-oxydative effects of miR-204 on LECs in age-related cataract

Authors: Su Xianhua,  Wang Ye,  Huang Yusen DOI: 10.3760/cma.j.issn.2095-0160.2016.03.008 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 227-233. Abstract Background miRNAs are a group of non-coding small RNA molecules, and they play an important role in regulating the apoptosis of LECs.The biological effects and mechanisams of miRNAs on LECs in age-related cataract still need to be further […]

Negative regulation of exogeneous polyl-4-hydroxylase domain proteins on hypoxia-inducible factor pathway in human RPE cells

Authors: Ma Yu,  Tang Shaohua,  Jiang Yanrong,  Shi Xuan DOI: 10.3760/cma.j.issn.2095-0160.2016.03.009 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 234-238. Abstract Background Anti-VEGF drugs are generally applied in the treatment of ocular neovascular diseases.However, the therapy effect is unsatisfactory in some patients.Studing the effect of hypoxia-inducible factor-1 (HIF-1), a upstream regulatory gene of VEGF, and its limiting enzyme […]

Clinical outcomes and safety of intra-capsular bag soft-shell technique during phacoemulsification for hard nuclear cataract

Authors: Han Wei,  Chen Binchuan,  Li Jiajia DOI: 10.3760/cma.j.issn.2095-0160.2016.03.010 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 239-243. Abstract Background Phacoemulsification for hard nuclear cataract is easy to cause corneal edema and posterior capsular rupture.Researches determined that soft-shell technique phacoemulsification can effectively reduce corneal edema, but the risk of posterior capsular rupture during the surgery is still […]

Identification of novel compound heterozygous mutations of USH2A gene in a RP pedigree by targeted-capture next generation sequencing

Authors: Wang Ying,  Huang Hui,  Fan Ning,  Wu Jing,  Zhou Xiaomin,  Yin Yan,  Wang Yun,  Liu Xuyang DOI: 10.3760/cma.j.issn.2095-0160.2016.03.011 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 244-247. Abstract Background RP is the term given to a set of hereditary retinal diseases.RP has groups of clinical characteristics and is a complex disease associated with distinct inheritance patterns.The screening and diagnosis of RP […]

Optical quality evaluation of pseudophakic eyes implanted different materials of IOL by optical quality analysis system

Authors: Wei Yinjuan,  Song Hui,  Tang Xin  DOI: 10.3760/cma.j.issn.2095-0160.2016.03.012 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 248-253. Abstract Background Phacoemulsification with IOL implantation can reduce the light scattering caused by cataract, but many patients with IOLs implantation complained of glare or blurred vision.IOLs from different materials will affect IOL refractive index (RI) and optical design, which […]