Authors: Li Yahong, Geng Chao, Hei Kaiwen, Liu Shengnan, Wang Qi, Li Xiaorong, Zhang Yan DOI: 10.3760/cma.j.cn115989-20200119-00033 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 676-685. Abstract [View PDF] [Read Full Text] Objective To investigate the damage effect of different concentrations of N-methyl-D-aspartic acid […]
Category: 2021
Bioinformatics analysis of transcriptome sequencing after the interference of extremely low frequency electromagnetic field in mouse fibroblasts
Authors: Zhu Maolin, Zhu Huang DOI: 10.3760/cma.j.cn115989-20200905-00633 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 686-692. Abstract [View PDF] [Read Full Text] Objective To analyze the changes in the transcriptome of mouse fibroblasts after exposure to extremely low frequency electromagnetic fields (ELF-EMFs) using next-generation […]
Protective effect of adeno-associated virus vector mediated heme oxygenase-1 overexpression on retinitis pigmentosa in rats
Authors: Liang Yuping, Chen Weiqi, Hong Yu, Gao Xiuyun, Guo Maosheng DOI: 10.3760/cma.j.cn115989-20201108-00754 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 693-699. Abstract [View PDF] [Read Full Text] Objective To investigate the protective effect of adeno-associated virus (AAV) vector-mediated heme oxygenase-1 (HO-1) gene overexpression […]
Relationship between BAP1, FOXO3 and ITPR2 gene expression and metastasis and prognosis of uveal melanoma
Authors: Li Yang, Feng Yu, Liu Yueming, Wei Wenbin DOI: 10.3760/cma.j.cn115989-20200714-00495 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 700-707. Abstract [View PDF] [Read Full Text] Objective To explore the potential biomarkers for the metastasis and prognosis of uveal melanoma (UM) from molecular genetics. […]
Genotypic and phenotypic analysis of RHO gene variants in a Chinese Han autosomal dominant retinitis pigmentosa family
Authors: Zhang Yuwei, Lou Guiyu, Yang Ke, Yang Lin, Zhu Qing, Lei Bo DOI: 10.3760/cma.j.cn115989-20201217-00848 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 708-713. Abstract [View PDF] [Read Full Text] Objective To analyze the pathogenic genes and clinical phenotypes of a Chinese Han family […]
Genetic testing and clinical phenotypic analysis of familial vitreous amyloidosis in two Han Chinese families
Authors: Zheng Wei, Li Haibo, Zhang Xueyong, Zhou Xuezhi, Chen Yuanyuan, Mao Junfeng DOI: 10.3760/cma.j.cn115989-20190721-00318 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 714-718. Abstract [View PDF] [Read Full Text] Objective To investigate the clinical characteristics of two Han families with familial vitreous amyloidosis […]
Clinical characteristics and genetic mutation analysis in a family with familial vitreous amyloidosis
Authors: Yu Qiang, Huang Xing, Yang Zhumin, Wang Xian DOI: 10.3760/cma.j.cn115989-20190923-00412 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 719-723. Abstract [View PDF] [Read Full Text] Objective To analyze the clinical characteristics and transthyretin (TTR) gene mutation of a family with familial vitreous amyloidosis […]
Efficacy evaluation of intravitreal injection of rAAV2-ND4 gene for Leber hereditary optic neuropathy
·Clinical Research· Evaluation of the efficacy of rAAV2-ND4 intravitreal injection for Leber’s hereditary optic neuropathy Li Xin1, Tian Zhen1, Chen Zhang 1, Li Bin1 ,2 ,3, Zhang Yong 1 1Department of Ophthalmology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan 442000, China; 2Department of Ophthalmology, Tongji Hospital, Tongji Medical College of Huazhong […]
Association between LIPC gene rs10468017 polymorphism and the susceptibility to age-related macular degeneration: a Meta-analysis
Authors: Gu Hong, Xu Zhangxing, Shen Zhaomeng, Li Zhiguo DOI: 10.3760/cma.j.cn115989-20191117-00498 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 729-736. Abstract [View PDF] [Read Full Text] Objective To systematically evaluate the association between the hepatic lipase (LIPC) gene rs10468017 polymorphism and susceptibility to age-related […]
Non-viral vector for gene therapy in inherited retinal degeneration
Authors: Wei Xing, Sui Ruifang DOI: 10.3760/cma.j.cn115989-20200627-00457 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 737-742. Abstract [View PDF] [Read Full Text] Inherited retinal degeneration (IRD), a group of diseases often causing irreversible blindness, with multiple pathogenesis, still lacks effective treatments currently.Development of effective […]