Category: Clinical Science

Clinical characteristics and genetic mutation analysis in a family with familial vitreous amyloidosis

Authors: Yu Qiang,  Huang Xing,  Yang Zhumin,  Wang Xian DOI: 10.3760/cma.j.cn115989-20190923-00412 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 719-723. Abstract Objective To analyze the clinical characteristics and transthyretin (TTR) gene mutation of a family with familial vitreous amyloidosis (FVA). Methods A pedigree investigation was performed.The clinical data of 20 family members of a […]

Efficacy evaluation of intravitreal injection of rAAV2-ND4 gene for Leber hereditary optic neuropathy

Authors: Li Xin,  Tian Zhen,  Chen Zhang,  Li Bin,  Zhang Yong DOI: 10.3760/cma.j.cn115989-20210330-00218 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 724-728. Abstract Objective To evaluate the safety and clinical effect of gene therapy for Leber hereditary optic neuropathy (LHON). Methods A multi-center prospective non-randomized controlled trial was conducted.Eighty eyes of 40 LHON patients […]

Association between LIPC gene rs10468017 polymorphism and the susceptibility to age-related macular degeneration: a Meta-analysis

Authors: Gu Hong,  Xu Zhangxing,  Shen Zhaomeng,  Li Zhiguo DOI: 10.3760/cma.j.cn115989-20191117-00498 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 729-736. Abstract Objective To systematically evaluate the association between the hepatic lipase (LIPC) gene rs10468017 polymorphism and susceptibility to age-related macular degeneration (AMD). Methods A systematic search was performed in both English databases (PubMed, Embase, […]

Peripheral retinal fluorescence features of ultra-wide fundus fluorescein angiography in normal fundus eyes

Authors: Wang Xiaoling,  Chen Changzheng,  Xu Amin,  Yi Zuohuizi,  He Lu,  Liu Juejun,  Zheng Hongmei DOI: 10.3760/cma.j.cn115989-20190426-00201 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 609-613. Abstract Objective To analyze the peripheral retinal fluorescence characteristics of normal fundus on ultra-wide field fluorescein angiography (UWFA) images. Methods A cross-sectional study was conducted.Ninety-five patients (190 eyes) […]

Optical coherence tomography angiography of macula in retinopathy of prematurity children with single treatment history

Authors: Zhao Xinyu,  Wu Zhenquan,  Zhang Guoming DOI: 10.3760/cma.j.cn115989-20201104-00740 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 614-618. Abstract Objective To observe the changes of macular morphology and best corrected visual acuity (BCVA) in children with retinopathy of prematurity (ROP) after single treatment of laser photocoagulation or intravitreal injection of ranibizumab (IVR) by optical […]

Risk factors and treatment outcome of recurrent acanthamoeba keratitis after corneal transplantation

Authors: Feng Lijuan,  Jia Yanni,  Li Fengjie,  Dong Chunxiao,  Shi Weiyun,  Wang Ting DOI: 10.3760/cma.j.cn115989-20200930-00673 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 619-625. Abstract Objective To investigate the risk factors and treatment outcome of recurrent Acanthamoeba keratitis (AK) after corneal transplantation. Methods A serial case-observational study was carried out.Twenty-eight eyes of 28 patients […]

Clinical manifestation and treatment of ocular immune reconstitution inflammatory response syndrome in acquired immunodeficiency syndrome patients with cytomegalovirus retinitis

Authors: Kong Wenjun,  Wei Wenbin,  Xie Lianyong,  Chen Chao,  Du Kuifang DOI: 10.3760/cma.j.cn115989-20200317-00179 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 626-631. Abstract Objective To investigate the ocular characteristics and treatment prognosis of ocular immune reconstruction inflammatory syndrome (IRIS) in patients with cytomegalovirus retinitis (CMVR) complicated with acquired immunodeficiency syndrome (AIDS). Methods A serial […]

Analysis of target cytokines affecting OCTA changes following anti-VEGF treatment in PCV eyes

Authors: Xu Qing,  Qiao Lei,  Gong Chaoju,  Feng Ruifang,  Liu Yalu,  Sun Yongcheng,  Zhang Yipeng,  Li Suyan DOI: 10.3760/cma.j.cn115989-20210319-00187 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 632-639. Abstract Objective To explore the predictability cytokines in aqueous humor affecting optical coherence tomography angiography (OCTA) parameters after anti-vascular endothelial growth factor (VEGF) treatment in patients […]

Comparison of modulation transfer function between the eyes after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis

Authors: Cui Tong,  Wang Yan,  Zhang Lin,  Cheng Wenbo,  Zhao Wei DOI: 10.3760/cma.j.cn115989-20210310-00159 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 515-521. Abstract Objective To investigate and compare the changes of modulation transfer function (MTF) after small-incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK). Methods A cohort study was conducted.One hundred […]

Changes of corneal anterior surface morphology and higher-order aberrations after Smart

Authors: Wang Shuhan,  Wang Guiqin,  Yu Aomiao,  Zhao Shaozhen,  Wei Ruihua,  Huang Yue DOI: 10.3760/cma.j.cn115989-20191119-00501 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 522-527. Abstract Objective To compare the changes of corneal asphericity and higher-order aberrations after smart pulse technology-assisted transepithelial photorefractive keratectomy (Smart) for low and moderate myopia and to investigate the changes […]