Category: Experimental Science

The feasibility of human adipose-derived mesenchymal stem cells induced to endothelial-like cells and the safety of induced cells intraocular application in a short period

Authors: Guo Kai,  Luo Yan,  Li Shiqing,  Tian Jingyi DOI: 10.3760/cma.j.issn.2095-0160.2019.11.006 Published 2019-11-10 Cite as Chin J Exp Ophthalmol, 2019,37(11): 880-883. Abstract                              [View PDF] [Read Full Text] Objective To evaluate the feasibility of differentiation of human adipose mesenchymal stem cells (hADSCs) into […]

Appilcation of polycaprolactone/collagen nanofibrous membranes in constituting tissue engineering retinal pigment epithelium

Authors: Tang Tian,  Chen Jie,  Deng Hua,  Yin Xiaoguang,  Fu Yan DOI: 10.3760/cma.j.issn.2095-0160.2019.11.007 Published 2019-11-10 Cite as Chin J Exp Ophthalmol, 2019,37(11): 884-887. Abstract                              [View PDF] [Read Full Text] Objective To explore the potential of polycaprolactone (PCL)/gelatin nanofibrous composite membrane in constituting tissue engineering retinal pigment […]

Purification and cultivation of mouse primary retinal microvascular pericytes based on pre-incubation

Authors: Liu Guanghui,  Lin Cuihong,  Yang Tianye,  Xu Chaoyang,  Zheng Yongzheng,  Zhao Li,  Meng Chun,  Pan Mingdong DOI: 10.3760/cma.j.issn.2095-0160.2019.10.002 Published 2019-10-10 Cite as Chin J Exp Ophthalmol, 2019,37(10): 774-778. Abstract                               [View PDF] [Read Full Text] Objective To establish a simple method for isolation, purification and cultivation of primary retinal microvascular pericytes (RMPs) from […]

Expression of proline hydroxylase 2 in the membrane of proliferative diabetic retinopathy

Authors: Zhang Han,  Lu Qiang,  Cui Wei DOI: 10.3760/cma.j.issn.2095-0160.2019.10.003 Published 2019-10-10 Cite as Chin J Exp Ophthalmol, 2019,37(10): 779-784. Abstract                              [View PDF] [Read Full Text] Objective To investigate the expression of proline hydroxylase 2 (PHD2) in the proliferatine membrane of proliferative diabetic retinopathy (PDR) and its relationship with […]

Inhibition of PTB-associated splicing factor on IGF-1/VEGF signaling pathway in retinal vascular endothelial cells

Authors: Tian Fang,  Dong Lijie,  Ji jie,  Zhou Yu,  Li Wenbo,  Bai Lingling,  Wang Fei,  Qi Chen,  Su Chang,  Zhang Xiaomin,  Li Xiaorong  DOI: 10.3760/cma.j.issn.2095-0160.2016.01.003 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 11-16. Abstract                            [Download PDF] [Read Full Text] Background Retinal neovascularization (RNV) is common findings of many fundus diseases.Research showed that insulin-like growth factor-1 […]

Promoting effect of p75NTR receptor overexpression on oxidative stress injury in human retinal pigment epithelium cells

Authors: Qi Yun,  Bai Yujing,  Li Xiaoxin,  Shi Xuan DOI: 10.3760/cma.j.issn.2095-0160.2016.01.004 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 17-23. Abstract                            [Download PDF] [Read Full Text] Background Choroidal neovascularization (CNV) is the primary pathogenic cause of many fundus diseases.Oxidative stress injury of retinal pigment epithelial (RPE) cells plays important […]

Inhibition of CCN1 siRNA on retinal endothelial cells

Authors: Di Yu,  Zhang Yiou,  Wang Aiyuan,  Chen Xiaolong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.005 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 24-29. Abstract                              [Download PDF] [Read Full Text] Background Cysteine-rich 61(Cyr61)/CCN1 has been reported to stimulate retinal neovascularization (RNV) in retinopathy of prematurity (ROP). However, whether CCN1 small interfering RNA […]

Inhibition of ADP-ribosylation factor antagonist on human retinal vascular endothelial cell tube formation in vitro

Authors: Wu Jing,  Liu Gaoqin,  Chen Zhigang,  Xiao Yanhui,  Xu Jing,  Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.006 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 30-34. Abstract                            [Download PDF] [Read Full Text] Background Researches showed that ADP-ribosylation factor (ARF) promotes intracorneal secretion of multiple angiogenesis-related factors, such as vascular endothelial growth factor (VEGF) […]

The protactive effects and mechanisms of cx3cr1 antibody on retinal neuron in rats with ischemia reperfusion injury by intravitreal injection

Authors: Li Juanjuan,  Li Yan,  Tang Zhiwei  DOI: 10.3760/cma.j.issn.2095-0160.2016.01.007 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 35-41. Abstract                            [Download PDF] [Read Full Text] Background Study confirmed that the active microglia may injure retinal ganglion cells (RGCs) in retinal ischemia reperfusion injury (IRI), and increased cx3cr1 expression is […]

Induce and differentiation of pig Müller cells into photoreceptors in vitro

Authors: Xu Ni,  Liu Yongqing,  Douglas C Dean,  Dong Fangtian DOI: 10.3760/cma.j.issn.2095-0160.2016.01.009 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 43-48. Abstract                               [Download PDF] [Read Full Text] Background Recent studies indicated that rat and mouse Müller cells can be induced and differentiated into photoreceptor-like cells in vitro, but […]