Authors: Cao Jingjie, Zhang Chen, Zhao Shaozhen, Wan Yizao, Hu Da DOI: 10.3760/cma.j.issn.2095-0160.2016.02.006 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 121-124. Abstract [Download PDF] [Read Full Text] Background Corneal transplantation is a primary method for the treatment of serious corneal diseases, but its application […]
Category: Experimental Science
Pathogenesis and treatment of overwhelming inflammation induced by Pseudomonas aeruginosa keratitis in rabbit
Authors: Liang Qingfeng, Li Bin, Zhang Yang, Labbe Antoine DOI: 10.3760/cma.j.issn.2095-0160.2016.02.007 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 125-131. Abstract [Download PDF] [Read Full Text] Background Infectious keratitis is common blinding eye disease in China. Inflammatory runaway reaction often occurs in infectious keratitis, and its mechanism and treating […]
Isolation and culture of corneal neovascular endothelial cells and expression of chemokine receptors
Authors: Liu Gaoqin, Xiao Yanhui, Chen Zhigang, Xu Jing, Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2016.02.008 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 132-136. Abstract [Download PDF] [Read Full Text] Background The pathogenesis and mechanism research of corneal neovascularization is of important significance for the prevention and management of corneal neovascularization. Some […]
Construction of Smac siRNA lentiviral vector and its silencing effect on Smac gene in human LECs
Authors: Li Yun, Zheng Guangying, Jiang Yu DOI: 10.3760/cma.j.issn.2095-0160.2016.03.002 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 199-204. Abstract [Download PDF] [Read Full Text] Background Research comfirmed that second mitochondrial activator of caspase (Smac) is a promoting tumor cell apoptosis protein.Our previous study showed that the expression […]
Expression and its significance of aquaporin0 and 1 in lens with age-related cataract
Authors: Zhan Zhiyun, Xu Guoxing, Xie Maosong DOI: 10.3760/cma.j.issn.2095-0160.2016.03.003 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 205-209. Abstract [Download PDF] [Read Full Text] Background Age-related cataract is a common cause of blindness.However, its cause and pathogenic mechanism have not been fully understood.Recent studies revealed that aquaporin 1 […]
In vitro epithelial-mesenchymal transition model for LECs of human posterior capsule opacification
Authors: Yang Baoxia, Wang Ye, Zhao Xiaowen, Liu Ting, Huang Yusen DOI: 10.3760/cma.j.issn.2095-0160.2016.03.004 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 210-217. Abstract [Download PDF] [Read Full Text] Background Epithelial-mesenchymal transition (EMT) is one of the pathogenesis mechanisms of posterior capule opcification (PCO). Studying EMT is of important significance […]
The regulation of estradiol on growth dynamics of human LECs affected by increasing telomerase activity
Authors: Wang Jie, Kang Gangjin, Yuan Xuefeng, Xu Manhua, Jiang Yan, Luo Bo DOI: 10.3760/cma.j.issn.2095-0160.2016.03.006 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 219-225. Abstract [Download PDF] [Read Full Text] Background Human LECs can express telomerase activity, which participates in the formation of cataract.It is reported that estrogen can increase […]
Anti-oxydative effects of miR-204 on LECs in age-related cataract
Authors: Su Xianhua, Wang Ye, Huang Yusen DOI: 10.3760/cma.j.issn.2095-0160.2016.03.008 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 227-233. Abstract [Download PDF] [Read Full Text] Background miRNAs are a group of non-coding small RNA molecules, and they play an important role in regulating the apoptosis of LECs.The biological effects […]
Negative regulation of exogeneous polyl-4-hydroxylase domain proteins on hypoxia-inducible factor pathway in human RPE cells
Authors: Ma Yu, Tang Shaohua, Jiang Yanrong, Shi Xuan DOI: 10.3760/cma.j.issn.2095-0160.2016.03.009 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 234-238. Abstract [Download PDF] [Read Full Text] Background Anti-VEGF drugs are generally applied in the treatment of ocular neovascular diseases.However, the therapy effect is unsatisfactory […]
Differentially expressed genes analysis of retinal vascular endothelial cells under hyperglycemia and hyperlipidemia induced by α-melanocyte-stimulating hormone
Authors:Wu Mianmian, Guo Fang, Li Yahong, Liu Ke, Zhang Yan DOI: 10.3760/cma.j.issn.2095-0160.2019.09.002 Published 2019-09-10 Cite as Chin J Exp Ophthalmol, 2019,37(9): 694-700. Abstract [View PDF] [Read Full Text] Objective To investigate the effect of α-melanocyte-stimulating hormone(α-MSH) on the expression of mRNA and long noncoding RNA (lncRNA) […]