Authors: Dai Hong, Lu Yingyi DOI: 10.3760/cma.j.issn.2095-0160.2016.01.001 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 1-4. Abstract [Download PDF] [Read Full Text] Neovascular age-related macular degeneration is also known as wet age-related macular degeneration (wAMD), which is now one of potentially blinding diseases in elder population worldwide.The […]
Category: 2016, No. 01
RP research in the era of precision medicine: discovery to translation
Authors: Yang Jing, Xiaowu Gai, Eric Pierce DOI: 10.3760/cma.j.issn.2095-0160.2016.01.002 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 5-10. Abstract [Download PDF] [Read Full Text] Retinitis pigmentosa (RP) encompasses many different hereditary retinal degenerations that are caused by a vast array of different gene mutations and have highly […]
Inhibition of PTB-associated splicing factor on IGF-1/VEGF signaling pathway in retinal vascular endothelial cells
Authors: Tian Fang, Dong Lijie, Ji jie, Zhou Yu, Li Wenbo, Bai Lingling, Wang Fei, Qi Chen, Su Chang, Zhang Xiaomin, Li Xiaorong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.003 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 11-16. Abstract [Download PDF] [Read Full Text] Background Retinal neovascularization (RNV) is common findings of many fundus diseases.Research showed that insulin-like growth factor-1 […]
Promoting effect of p75NTR receptor overexpression on oxidative stress injury in human retinal pigment epithelium cells
Authors: Qi Yun, Bai Yujing, Li Xiaoxin, Shi Xuan DOI: 10.3760/cma.j.issn.2095-0160.2016.01.004 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 17-23. Abstract [Download PDF] [Read Full Text] Background Choroidal neovascularization (CNV) is the primary pathogenic cause of many fundus diseases.Oxidative stress injury of retinal pigment epithelial (RPE) cells plays important […]
Inhibition of CCN1 siRNA on retinal endothelial cells
Authors: Di Yu, Zhang Yiou, Wang Aiyuan, Chen Xiaolong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.005 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 24-29. Abstract [Download PDF] [Read Full Text] Background Cysteine-rich 61(Cyr61)/CCN1 has been reported to stimulate retinal neovascularization (RNV) in retinopathy of prematurity (ROP). However, whether CCN1 small interfering RNA […]
Inhibition of ADP-ribosylation factor antagonist on human retinal vascular endothelial cell tube formation in vitro
Authors: Wu Jing, Liu Gaoqin, Chen Zhigang, Xiao Yanhui, Xu Jing, Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.006 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 30-34. Abstract [Download PDF] [Read Full Text] Background Researches showed that ADP-ribosylation factor (ARF) promotes intracorneal secretion of multiple angiogenesis-related factors, such as vascular endothelial growth factor (VEGF) […]
The protactive effects and mechanisms of cx3cr1 antibody on retinal neuron in rats with ischemia reperfusion injury by intravitreal injection
Authors: Li Juanjuan, Li Yan, Tang Zhiwei DOI: 10.3760/cma.j.issn.2095-0160.2016.01.007 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 35-41. Abstract [Download PDF] [Read Full Text] Background Study confirmed that the active microglia may injure retinal ganglion cells (RGCs) in retinal ischemia reperfusion injury (IRI), and increased cx3cr1 expression is […]
Induce and differentiation of pig Müller cells into photoreceptors in vitro
Authors: Xu Ni, Liu Yongqing, Douglas C Dean, Dong Fangtian DOI: 10.3760/cma.j.issn.2095-0160.2016.01.009 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 43-48. Abstract [Download PDF] [Read Full Text] Background Recent studies indicated that rat and mouse Müller cells can be induced and differentiated into photoreceptor-like cells in vitro, but […]
Contrast of retinal structure and function developing of premature rats versus full-term newborn rats
Authors: Yang Xiangmin, Li Rong, Wang Yusheng, Su Jingbo, An Jing, Chen Tao, Cao Qinglin, Zhang Zuoming DOI: 10.3760/cma.j.issn.2095-0160.2016.01.010 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 49-55. Abstract [Download PDF] [Read Full Text] Background Premature birth is a high risk factor of abnormal development in the morphology and function of vision system.To […]
Expression changes of brain-derived neurotrophic factor in retina of oxygen-induced retinopathy
Authors: Duan Haixia, Guo Kai, Wang Banwei DOI: 10.3760/cma.j.issn.2095-0160.2016.01.011 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 56-59. Abstract [Download PDF] [Read Full Text] Background Neovascular diseases such as retinopathy of prematurity often leads to irreversible vision loss.The study on oxidative damage mechanism is becoming more and […]