Changes of lens thickness, anterior chamber depth and influence factors in normal subjects

Authors: Wang Huan,  Song Hui,  Tang Xin
DOI: 10.3760/cma.j.issn.2095-0160.2015.07.017
Published 2015-07-10
Cite as Chin J Exp Ophthalmol, 2015,33(7): 650-654.

Abstract                            [Download PDF] [Read Full Text]


The study on influences of gender, age and axial length (AL) on lens thickness (LT) and anterior chamber depth (ACD) in normal population is still lack in China.


This study was to measure LT and ACD in normal subjects and discuss their changes with age, gender and AL.


AL, ACD and LT were measured on 866 eyes of 433 normal population with Lenstar LS900 in Tianjin Eye Hospital from March through December in 2013, including 390 eyes in 195 males and 476 eyes of 238 females. ACD/AL, LT/AL and (ACD+ LT)/AL were calculated after measurement. The subjects were grouped to the 10-20 years group, 21-30 years group, 31-40 years group, 41-50 years group, 51-60 years group and ≥61 years group based on age, or the 22 mm≤AL<24 mm group, 24 mm≤AL<26 mm group and AL≥26 mm based on AL, and the measured parameters were compared and analyzed among the groups. Oral informed consent was obtained from each subject or child contutor prior to any medical examination.


AL, ACD and LT values were (24.41±1.37), (2.89±0.42) and (4.05±0.52) mm in the males, and those in the females were (23.83±1.31), (2.72±0.40) and (4.20±0.44) mm, showing significant differences between them (t=6.278, 6.102, -4.595, all at P=0.000). No significant differences were found in ACD, LT, ACD/AL, LT/AL and (ACD+ LT)/AL values between the right eyes and the left eyes (t=-0.713, 0.186, -0.754, 0.296, -0.168, all at P>0.05). As the increase of the AL, ACD was remarkable deepened but LT was declined, with the considerable difference among the 22 mm≤AL<24 mm group, 24 mm≤AL<26 mm group and AL≥26 mm group (F=176.640, 94.569, both at P=0.000). ACD value was higher, but LT value was lower in the 24 mm≤AL<26 mm group or AL≥26.00 mm group than that in the 22 mm≤AL<24 mm group (all at P<0.05). ACD value was gradually reduced, while LT value was elevated with aging, with significant differences among the different age groups (F=104.531, 373.225, all at P=0.000). Significant correlations were found between age and ACD, LT or (ACD+ LT)/AL, with the regression equations of ACD (mm)=-0.015×age+ 3.434 (F=-22.979, P=0.000); LT (mm)=0.024×age+ 3.122 (F=44.856, P=0.000), LT/AL=0.001×age+ 0.122 (F=37.982, P=0.000), (ACD+ LT)/AL=0.001×age+ 0.259 (F=22.451, P=0.000).


Compared with normal females, males have thinner LT and deeper ACD. In the normal eyes, longer AL is, thinner LT is and the deeper ACD is. LT thickens and ACD deepens with aging.

Key words:

Bio-measurement; Lens/anatomy; Anterior chamber/anatomy; Axis, ocular; Age; Gender; Humans

Contributor Information

Wang Huan
Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin Medical University, Tianjin 300020, China
Song Hui
Tang Xin
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Updated: March 30, 2023 — 7:43 am