Chinese expert consensus on the diagnosis and management of eye pseudoexfoliation syndrome (2025)

Pseudoexfoliation syndrome (PEX) is a systemic, age-related, multi-factor disorder of extracellular matrix metabolism characterized by the abnormal production and progressive accumulation of fibrillar pseudoexfoliative material in ocular tissues and multiple systemic organs.Globally recognized as a leading cause of secondary glaucoma and cataract formation, PEX often presents with subtle or nonspecific early clinical manifestations.This insidious onset often leads to underdiagnosis or misdiagnosis due to insufficient awareness among clinicians and patients, ultimately contributing to irreversible vision loss and diminished quality of life.Currently, the lack of globally standardized diagnostic and therapeutic protocols for PEX hampers its effective clinical management.To address these challenges, we employed a modified Delphi consensus methodology to systematically identify critical issues encountered by ophthalmologists in the management of PEX.Based on a comprehensive review of the international literature and incorporating clinical insights from experts, we conducted rigorous multidisciplinary deliberations on key aspects of PEX, including its epidemiology, risk factors, molecular pathogenesis, diagnostic criteria, differential diagnosis, evidence-based treatment strategies, and long-term follow-up protocols.This collaborative effort culminated in an evidence-driven expert consensus aimed at standardizing clinical practice and improving patient outcomes in the treatment of PEX.

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