Comparison of efficacy between intravitreal injection of conbercept with and without macular photocoagulation for diabetic macular edema

Authors: Jiang Li,  Luo Xiaoling,  Qin Bo,  Deng Tingming,  Yang Mingming
DOI: 10.3760/cma.j.cn115989-20201104-00746
Published 2022-01-10
Cite asChin J Exp Ophthalmol, 2022, 40(1): 41-46.

Abstract                              [View PDF] [Read Full Text

Objective

To compare the clinical efficiency and safety between intravitreal injection of conbercept with and without macular photocoagulation for diabetic macular edema (DME).

Methods

A non-random controlled study was conducted.Sixty patients (60 eyes) with DME treated in Shenzhen People’s Hospital from January 2017 to January 2020 were enrolled. The patients receiving intravitreal injection of conbercept alone were divided into conbercept injection group (33 cases, 33 eyes), and those who underwent macular photocoagulation combined with intravitreal injection of conbercept were divided into combined treatment group (27 cases, 27 eyes). Best corrected visual acuity (BCVA) was examined using Early Treatment of Diabetic Retinopathy Study.The BCVA, central macular thickness (CMT) and fluorescein fundus angiography (FFA) examination were performed to observe the changes of macular edema and leakage area before and at 1, 3, 6, 9 and 12 months after treatment.The injection frequency, ocular and systemic complications were recorded.This study protocol adhered to the Declaration of Helsinki and was approved by an Ethics Committee of Shenzhen Pepole’s Hospital (No.LL-YK-20170405). Written informed consent was obtained from each patient prior to any medical examination.

Results

There were better mean BCVA and lower CMT at 1, 3, 6, 9 and 12 months after treatment compared with the BCVA and CMT before treatment in the two groups (all at P<0.05). At 12 months after treatment, FFA showed that the improvement rate of macular edema was 91.0% (30/33) in the conbercept injection group and 96.3% (26/27) in the combined treatment group, showing a statistically significant difference between them (χ2=3.430, P<0.05). The injection frequency was (4.36±1.62) times in the conbercept injection group, which was significantly higher than (3.41±0.64) times in the combined treatment group (t=9.211, P<0.05). No ocular adverse events, including ocular hypertension, endophthalmitis and retinal pigment epithelial tears or systemic complications were found during the follow-up.

Conclusions

Intravitreal injection of conbercept with or without macular photocoagulation can both maintain or improve visual acuity and alleviate exudative macular edema.They both show good safety, and the combined therapy has better long-term efficacy than conbercept alone.

Key words:

Macular edema/therapeutics; Laser coagulation; Conbercept; Intravitreal injections

Contributor Information

Jiang Li

Department of Ophthalmology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

Luo Xiaoling

Department of Ophthalmology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

Qin Bo

Department of Ophthalmology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

Deng Tingming

Department of Ophthalmology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

Yang Mingming

Department of Ophthalmology, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

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