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To systemically evaluate the characteristics of cytokine levels in intraocular fluid of neovascular glaucoma (NVG).
Literature on the detection of cytokine levels in NVG published before June 2022 was searched in PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang databases, and China Science and Technology Journal Database (VIP).Two investigators independently completed the literature search, inclusion, and data extraction following the inclusion and exclusion criteria.Quantitative analyses were performed using Stata 16.0 software.Study heterogeneity was assessed using the I2 test, and effects were combined using the appropriate effect model to complete the meta-analysis.
A total of 24 studies were screened, including 771 NVG cases and 727 age-related cataract cases (control group).The standardized mean difference (SMD) of the combined effect value of vascular endothelial growth factor (VEGF) mass concentration in the aqueous humor between the two groups was 8.79, with a 95% confidence interval (CI) of 6.43 to 11.14.The SMD of interleukin-6 (IL-6) between the two groups was 12.50, with a 95%CI of 9.41 to 15.58.The VEGF and IL-6 levels in aqueous humor and vitreous humor were significantly higher in NVG group than in control group (all at P<0.05).The pigment epithelium-derived factor (PEDF) level in aqueous humor was lower in NVG group than in control group (SMD: -3.03, 95%CI: -5.50–0.55, P<0.05).The levels of IL-8 (SMD: 3.99, 95%CI: 1.14-6.85), erythropoietin (EPO) (SMD: 9.62, 95%CI: 0.44-18.79), placental growth factor (PIGF) (SMD: 2.62, 95%CI: 1.38-3.86), tumor necrosis factor-α (TNF-α) (SMD: 3.37, 95%CI: 1.87-4.87) were all significantly higher in NVG group than in control group (all at P<0.05).There was no significant difference in IL-1β level in aqueous humor between the two groups (P>0.05).
In NVG patients, VEGF, IL-6, IL-8, EPO, PIGF, TNF-α levels are obviously increased and PEDF level is obviously decreased.These biomarkers can be used as potential predictors or therapeutic targets for NVG.
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The Eye Hospital, School of Ophthalmology and Optometry, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China
Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fujian Institute of Ophthalmology, Fuzhou 350004, China
The Eye Hospital, School of Ophthalmology and Optometry, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China
The Eye Hospital, School of Ophthalmology and Optometry, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China
The Eye Hospital, School of Ophthalmology and Optometry, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China
The Eye Hospital, School of Ophthalmology and Optometry, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China
The Eye Hospital, School of Ophthalmology and Optometry, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China