Development and challenge of human lentoid bodies generation

Authors: Fu Qiuli,  Yao Ke
DOI: 10.3760/cma.j.cn115989-20220114-00015
Published 2022-05-10
Cite asChin J Exp Ophthalmol, 2022, 40(5): 385-388.

Abstract

Organoid is one of the hottest areas of research in the field of stem cells, which is an organ in a dish with three-dimensional structure and physiological functions that are highly similar to organs in vivo.At present, the generation methods of lens organoids, namely the lentoid bodies, have been established and continuously developed.The double-convex transparent lentoid bodies, with refractive function and all microscopic components of natural lenses, act as reliable in vitro models of human lenses and provide convenience for studying the mechanism of lens development.Moreover, the establishment of age-related cataract and congenital cataract models based on the lentoid bodies also provides great convenience and reliability for the study of pathological mechanism of cataract and drug screening, showing broad prospects in basic research and even clinical transformation for cataract.

Key words:

Lentoid bodies; Lens; Organoids; Stem cells; Cataract

Contributor Information

Fu Qiuli

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University Eye Hospital, Hangzhou 310009, China

Yao Ke

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University Eye Hospital, Hangzhou 310009, China

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