Effect of apelin/APJ in retinal vascular diseases

Authors: Chen Li,  Bai Yujing,  Jiang Yanrong

DOI: 10.3760/cma.j.issn.2095-0160.2017.10.018
Published 2017-10-10
Cite as Chin J Exp Ophthalmol, 2017,35(10): 936-939.

Abstract

The G protein-coupled receptor was deorphanized with cloning of the APJ-endogenous ligand apelin, which is an important active peptides.Apelin/APJ system is widely distributed in central nervous system, cardiovascular system, immune system and endocrine system.Therefore, apelin plays important physiological and pathological roles in blood pressure regulation, fluid homeostasis, potent inotropic, insulin sensitivity regulation, pituitary hormone release, human immunodeficiency virus (HIV) entry inhibition, etc.Recently, the studies found apelin/APJ system also regulates the vasculogenesis and angiogenesis of retina through inducing cell proliferation, migration and tube formation in endothelium.The experiments in vivo also demonstrate apelin/APJ system plays a role in physiological and pathological retinal vascular formation.This review summarizes the evidence of apelin in physiological retinal vascular diseases and diabetic retinopathy, retinopathy of prematurity and choroidal neovascular ization.

Key words:

Apelin; APJ; Retina; Angiogenesis

Contributor Information

Chen Li
Department of Ophthalmology, People’s Hospital, Peking University & Key Laboratory of Vision Loss and Restoration, Ministry of Education & Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China(Chen Li, now Department of Ophthalmology, Beijing Jiangong Hospital)
Bai Yujing
Jiang Yanrong
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Updated: September 4, 2019 — 1:52 pm