Role of Hedgehog signaling pathway in the development of retinal cells and pathological angiogenesis

Authors: Liu Meilin,  Di Yu,  Chen Xiaolong

DOI: 10.3760/cma.j.issn.2095-0160.2017.10.019
Published 2017-10-10
Cite as Chin J Exp Ophthalmol, 2017,35(10): 940-943.

Abstract

The pathological growth of retinal cells and ocular pathologic angiogenesis can be seen in a variety of eye diseases, which seriously affect the visual acuity of patients.The Hedgehog signal pathway has been demonstrated to be involved in the development of retinal ganglion cells, amacrine cells, cone cells and rod cells, Müller glial cells and retinal pigment epithelial cells.This paper discusses the function of Hedgehog signal pathway in the development of retinal cells and ocular pathologic angiogenesis, which may provide a new therapeutic target for retinal and ocular vascular diseases.

Key words:

Hedgehog signaling pathway; Retina; Vascular development; Pathologic angiogenesis

Contributor Information

Liu Meilin
Department of Ophthalmology, Shengjing Hospital Attached to China Medical University, Shenyang 110004, China
Di Yu
Chen Xiaolong
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Updated: September 4, 2019 — 1:51 pm