Effects of 0.3% sodium hyaluronate ophthalmic solution in the treatment of mild-to-moderate dry eye patients: a multi-center clinical study

Authors: Huang Caihong,  Liu Zuguo,  Li Wei,  Zhu Li,  Zhu Sisi,  Lin Xiang,  Ouyang Weijie,  Jiang Nan,  Xu Jianjiang,  Wu Dan,  Liang Lingyi,  Luo Xiaohui,  Wang Hua,  Chen Ting,  Chen Wei,  Zheng Qinxiang,  Sun Xuguang,  Deng Shijing

DOI: 10.3760/cma.j.issn.2095-0160.2018.12.008
Published 2018-12-10
Cite as Chin J Exp Ophthalmol, 2018,36(12): 936-941.

Abstract

Objective

To evaluate the efficacy of 0.3% sodium hyaluronate ophthalmic solution in mild-to-moderate dry eye patients.

Methods

A prospective, multicenter, and self-controlled clinical trial was performed on 200 patients who were diagnosed as mild-to-moderate dry eye from January 2015 to June 2017 in Eye Institute of Xiamen University, Eye & ENT Hospital of Fudan University, Zhongshan Ophthalmic Center, Xiangya Hospital Central South University, Eye Hospital of Wenzhou Medical University, and Beijing Tongren Hospital, Capital Medical University.The study protocol was approved by the Ethics Committees of Eye Institute of Xiamen University, written informed consent was obtained from each patient prior to any medical examination.All patients were treated with 0.3% sodium hyaluronate ophthalmic solution 6 times per day (one drop each time) for 28 days.Corneal fluorescein sodium staining, tear film break-up time (BUT), SchirmerⅠtest (SⅠt), degree of conjunctival hyperemia, eyelid margin, meibomian gland secretion, secretory capacity of meibomian gland and subjective symptoms were assessed at baseline, on the 14th day and 28th day after treatment.Bulbar impression cytology was evaluated at baseline and on the 28th day after treatment.Irritation of 0.3% sodium hyaluronate ophthalmic solution was estimated on the 14th day and 28th day after treatment.

Results

The total score of subjective symptoms, BUT, SⅠt, degree of conjunctival hyperemia were significantly different among different treatment time points(F=108.969, 27.598, 16.838, 36.750; all at P<0.01). Compared with before treatment, the total score of subjective symptoms was significantly decreased, the degree of conjunctival hyperemia and the total corneal fluorescein sodium staining point number were significant decreased on the 14th day and 28th day after treatment.The total score of subjective symptoms, degree of conjunctival hyperemia and total corneal fluorescein sodium staining point number on the 28th day after treatment were significant lower than those on the 14th day after treatment.Compared with before treatment, the BUT was significantly longer and the SⅠt scores were significantly increased on the 14th day and 28th day after treatment.The BUT on the 28th day after treatment was significantly longer than that on the 14th day after treatment; no significant difference in SⅠt was observed between the 28th day and the 14th day after treatment.The scores of palpebral margin change, meibomian gland secretory ability and secretion characteristics were not significantly different among different treatment time points(H=0.255, 2.356, 0.294; all at P>0.05). The impression cytology grade on the 28th day after treatment was 1.08±0.74, which was significantly lower than 1.53±0.76 before treatment (t=5.979, P<0.01). The number of goblet cells on the 28th day after treatment was significantly higher than that before treatment(U=1 806.500, P<0.01). On the 14th day after treatment, 70% of the patients indicated that the drug was non-irritating, and no patient had intolerable irritation affecting daily lives.All patients had good tolerance to this drug.

Conclusions

The use of 0.3% sodium hyaluronate eye drops can improve the symptoms and signs of mild to moderate dry eye, which can be widely used for mild-to-moderate dry eye patients in clinic.

Key words:

Dry eye; Sodium hyaluronate; Tear film; Multi-center clinical study

Contributor Information

Huang Caihong
Eye Institute of Xiamen University, Xiang’an Hospital Affiliated to Xiamen University, Xiamen Eye Center Affiliated to Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China
Liu Zuguo
Eye Institute of Xiamen University, Xiang’an Hospital Affiliated to Xiamen University, Xiamen Eye Center Affiliated to Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China
Li Wei
Eye Institute of Xiamen University, Xiang’an Hospital Affiliated to Xiamen University, Xiamen Eye Center Affiliated to Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China
Zhu Li
The Second Hospital University of South China, Hengyang 421001, China
Zhu Sisi
The Second Hospital University of South China, Hengyang 421001, China
Lin Xiang
Eye Institute of Xiamen University, Xiang’an Hospital Affiliated to Xiamen University, Xiamen Eye Center Affiliated to Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China
Ouyang Weijie
Eye Institute of Xiamen University, Xiang’an Hospital Affiliated to Xiamen University, Xiamen Eye Center Affiliated to Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China
Jiang Nan
Eye Institute of Xiamen University, Xiang’an Hospital Affiliated to Xiamen University, Xiamen Eye Center Affiliated to Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China
Xu Jianjiang
Eye & ENT Hospital of Fudan University, Shanghai 200031, China
Wu Dan
Eye & ENT Hospital of Fudan University, Shanghai 200031, China
Liang Lingyi
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
Luo Xiaohui
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
Wang Hua
Xiangya Hospital Central South University, Changsha 410008, China
Chen Ting
Xiangya Hospital Central South University, Changsha 410008, China
Chen Wei
The Eye Hospital of Wenzhou Medical University, Wenzhou 325035, China
Zheng Qinxiang
The Eye Hospital of Wenzhou Medical University, Wenzhou 325035, China
Sun Xuguang
Beijing Tongren Hospital, Capital Medical University, Beijing 100069, China
Deng Shijing
Beijing Tongren Hospital, Capital Medical University, Beijing 100069, China
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