Effects of small leucine-rich proteoglycans on corneal transparency

Authors: Han Han,  He Yuxi,  Zhang Yan
DOI: 10.3760/cma.j.cn115989-20210222-00124
Published 2022-03-10
Cite asChin J Exp Ophthalmol, 2022, 40(3): 266-270.

Abstract

Small leucine-rich proteoglycans (SLRPs) are necessary structural ingredients of the cornea, which are vital for the establishment and maintenance of corneal transparency.SLRPs are mainly located in the corneal stroma and can be divided into class Ⅰ, class Ⅱ, and class Ⅲ.The compensatory and cooperative interactions among SLRPs regulate the formation and assembly of stromal collagen fibrils, thereby maintaining the highly ordered arrangement of collagen fibrils, and establishing corneal transparency.Decorin and lumican are the main functional components of class Ⅰ and class Ⅱ SLRPs, respectively, and changes in their expression or abnormities in the structure of their core proteins affect the natural content and arrangement of other stromal extracellular matrix components, ultimately resulting in abnormal fibril formation, assembly, and arrangement, causing corneal opacity.SLRPs can regulate corneal wound healing and stromal matrix remodeling via binding to fibrotic molecules and their receptors, which provides bases for corneal diseases therapy and study of molecular mechanisms of corneal transparency.The bioactivities and the role of SLRPs in corneal transparency were reviewed in this article.

Key words:

Small leucine-rich proteoglycans; Corneal opacity; Corneal stroma; Collagen fibril; Corneal wound healing

Contributor Information

Han Han

Department of Corneal Refraction, Eye Center, The Second Hospital of Jilin University, Changchun 130041, China

He Yuxi

Department of Corneal Refraction, Eye Center, The Second Hospital of Jilin University, Changchun 130041, China

Zhang Yan

Department of Corneal Refraction, Eye Center, The Second Hospital of Jilin University, Changchun 130041, China

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