Meta-analysis of retinal vein occlusion risk factors

Authors: Li Zefeng,  Zhou Xiyuan,  Liu Danning

DOI: 10.3760/cma.j.issn.2095-0160.2020.03.007
Published 2020-03-10
Cite as Chin J Exp Ophthalmol, 2020,38(03): 192-199.

Abstract                              [View PDF] [Read Full Text]


To evaluate the risk factors for retinal vein occlusion(RVO) through a meta-analysis.


The literatures on risk factors of RVO were searched in the Cochrane library, PubMed, and Embase databases.The literature search time ranged from the establishment of database to December 2018.The literatures were evaluated and filtrated by using Newcastle-Ottawa Scale, Stata software (version 12.0) was used for data processing.


A total of 31 case-control studies with 4 370 cases and 6 534 controls were included.The meta-analysis showed that hypertension (odds ratio[OR]=3.08, 95% confidence interval [CI]: 2.22-4.28), diabetes (OR=1.61, 95% CI: 1.11-2.32), hyperlipidemia (OR=1.73, 95% CI: 1.27-2.36), hyperlipoprotein (a)-emia (OR=2.72, 95% CI: 1.06-6.97), hyperhomocysteinemia (OR=1.86, 95% CI: 1.47-2.35), mutation of coagulation factor V Leiden gene (OR=1.89, 95% CI: 1.17-3.06) were risk factors for RVO.However, mutation of gene MTHFR C677T (OR=1.41, 95% CI: 0.93-2.14)、mutation of prothrombin gene G20210A (OR=1.20, 95% CI: 0.81-1.79) were not found to be risk factors for RVO.Subgroup analysis showed that the heterogeneity of hypertension and diabetes among people aged over 60 decreased from 88.9% and 75.7% to 59.8% and 63.2%, respectively.The heterogeneity of hyperhomocysteinemia in people aged below 60 decreased from 85.6% to 64.3%.The sensitivity analysis results showed that there were no significant differences after changing the analysis model.There was no publication bias among the literatures.


Hypertension, diabetes, hyperlipidemia, hyperhomocysteinemia, hyperlipoprotein (a)-emia, mutation of coagulation factor V Leiden gene are risk factors for retinal vein occlusion.

Key words:

Retinal vein occlusion; Risk factors; Meta-analysis

Contributor Information

Li Zefeng
Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Zhou Xiyuan
Liu Danning
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Updated: December 27, 2022 — 7:32 am