Neuroprotection and neuroregeneration treatment strategy in non-arteritic anterior ischemic optic neuropathy

Authors: Chou Yuyu,  Ma Jin,  Zhong Yong
DOI: 10.3760/cma.j.cn115989-20190615-00261
Published 2022-07-10
Cite asChin J Exp Ophthalmol, 2022, 40(7): 675-679.

Abstract                                       [View PDF] [Read Full Text]

Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease characterized by acute, painless visual acuity loss and visual field impairment, and there is still lack of unified and effective treatment.As new therapeutic strategies, neuroprotection and nerve regeneration have aroused wide public concern, which aim to prevent degeneration and death of neurons or establish a new neural circuit through inhibiting apoptosis pathway and inflammation, promoting axon growth and applying stem cells.Plenty of studies have applied the strategies to NAION patients or NAION animal models, which achieved certain success, but the limitations exist at the same time.For the sake of exploring practical therapies of NAION, researches on the neuroprotection and nerve regeneration strategies of NAION in recent years were reviewed in this article.

Key words:

Optic neuropathy; Ischemic/therapy; Neuroprotection; Nerve regeneration

Contributor Information

Chou Yuyu

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &

Peking Union Medical College, Beijing 100730, China

Ma Jin

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &

Peking Union Medical College, Beijing 100730, China

Zhong Yong

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &

Peking Union Medical College, Beijing 100730, China

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