Role of NLRP3 inflammasome signaling pathway in the occurrence and development of diabetic keratopathy

Authors: Wan Luqin,  Zhou Qingjun,  Xie Lixin
DOI: 10.3760/cma.j.cn115989-20190618-00266
Published 2022-07-10
Cite asChin J Exp Ophthalmol, 2022, 40(7): 680-684.

Abstract                                       [View PDF] [Read Full Text]

Diabetic keratopathy is a chronic complication of diabetes caused by abnormal metabolites accumulation, oxidative stress, abnormal inflammation and corneal neuropathy.It can result in delayed corneal epithelial healing and decreased corneal sensitivity under the stimulation of ocular trauma or surgery which bring great challenges to clinicians.Activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammatory is one of the factors that cause chronic complications of diabetes, and is also an important factor for delaying the healing of diabetic wounds.The NLRP3 inflammatory signaling pathway is closely related to corneal oxidative stress, delayed epithelium healing and development of corneal neuropathy.In this paper, the research status and prospects of NLRP3 inflammatory signaling pathway and diabetic keratopathy were reviewed to provide new ideas for studying the mechanism and treatment of diabetic keratopathy.

Key words:

Diabetes/complications; Diabetic keratopathy; Inflammasomes/metabolism; Nucleotide-binding oligomerization domain-like receptor protein 3

Contributor Information

Wan Luqin

Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao 266071, China

Zhou Qingjun

Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

Xie Lixin

Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

(Read 3 times, 1 visits today)