Physiological role and neuroprotective effects of somatostatin in retina

Authors: Zhang Yi,  Sun Xinghuai,  Wang Zhongfeng
DOI: 10.3760/cma.j.cn115989-20191112-00492
Published 2021-10-10
Cite asChin J Exp Ophthalmol, 2021, 39(10): 915-918.

Abstract

Somatostatin, also called somatotropin release-inhibiting factor (SRIF), is a kind of neurotransmitter, neuromodulator and neurotrophic factor, which participates in a variety of physiological functions in the central nervous system by activating the five G-protein-coupled receptors (sst1-sst5). SRIF and its receptors are extensively expressed and distributed in retina.Activation of SRIF receptors modulates voltage-gated K+ and Ca2+ channels, and regulates multiple intracellular signaling pathways in retinal cells, then influences neurotransmitter release and synaptic transmission, which plays an important role in the regulation of retinal visual information processing.In addition, SRIF and its receptors may provide protective effects against retinal injuries, such as retinal ischemia, excitotoxic injury and diabetic retinopathy.In this article, connected with related previous researches of our team, the distribution of SRIF and its receptor in retina, as well as the role of SRIF and its receptor in the physiological regulation and neuroprotection of retina were reviewed.

Key words:

Somatostatin; Somatostatin receptor; Retina; Neuroprotection

Contributor Information

Zhang Yi

Department of Ophthalmology, Eye &

ENT Hospital, Fudan University, Shanghai 200031, China

Sun Xinghuai

Department of Ophthalmology, Eye &

ENT Hospital, Fudan University, Shanghai 200031, China

Wang Zhongfeng

Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China

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Updated: October 11, 2021 — 1:16 am