Role of lncRNA in the proliferation mechanism of Tenon fibroblasts

Authors: Cheng Yue,  Wang Feng,  Su Ying
DOI: 10.3760/cma.j.cn115989-20190627-00279
Published 2021-10-10
Cite asChin J Exp Ophthalmol, 2021, 39(10): 919-922.

Abstract

At present, the mechanism of scar formation in filtering area after glaucoma filtering surgery has not been fully understood.It is believed that stimulation of cytokines and growth factors during postoperative wound healing causes excessive activation of fibroblasts in the Tenon capsule, resulting in the deposition of extracellular matrix and scar formation.Long non-coding RNA (lncRNA) is a kind of RNA sequence that does not encode proteins.It can regulate cell proliferation, apoptosis and become a precursor of microRNA, and its specific expression has been proved and plays an important regulatory role in various fibrotic tissue.With the deepening of research, lncRNA has also been found to be involved in the formation and development of filtering bleb scarring after glaucoma filtering surgery.Previous studies have shown that lncRNA is specifically expressed in Tenon capsule tissues after glaucoma filtering surgery, and different lncRNAs can affect the proliferation of fibroblasts in Tenon capsule or the synthesis of extracellular matrix through different ways, which can affect the formation of fibroblasts scarring.In this article, the role of different lncRNAs in the proliferation of Tenon fibroblasts and its potential in treating bleb scarring were summarized so as to provide a new direction for the treatment of postsurgical scarring.

Key words:

Glaucoma; Filtration surgery, glaucoma; Long non-coding RNA; Fibrosis; Tenon fibroblast; Cell proliferation

Contributor Information

Cheng Yue

Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Wang Feng

Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Su Ying

Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

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Updated: October 11, 2021 — 1:15 am