Research progress in corneal neovascularization and microenvironment

Authors: Hou Peili,  Lu Yan,  Huang Zhenping

DOI: 10.3760/cma.j.issn.2095-0160.2016.02.019
Published 2016-02-10
Cite as Chin J Exp Ophthalmol, 2016,34(2): 184-188.


In a variety of pathological conditions, capillaries grow from corneal limbus to the central cornea area, to form corneal neovascularization (CNV). CNV destroys the normal corneal microenvironment, reduces the transparency of cornea, seriously affects visual acuity and leads to corneal transplantation immune rejection. Corneal microenvironment includes inflammatory mediators, cytokines and extracellular matrix (ECM). Studies showed that corneal microenvironment changes have a close relationship with CNV. This article reviewed the relationship of corneal microenvironment with CNV.

Key words:

[Key words]Corneal neovascularization; Microenvironment; Extracellular matrix

Contributor Information

Hou Peili
Department of Ophthalmology, School of Medicine, Nanjing General Hospital of Nanjing Military Command PLA, Nanjing University, Nanjing 210002, China
Lu Yan
Huang Zhenping
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Updated: October 10, 2019 — 2:49 am