Category: 2016, No. 02

Paying attention to proteomics of human tear: clinical significance and application in ocular surface diseases

Authors: Zhou Lei,  Liu Danning DOI: 10.3760/cma.j.issn.2095-0160.2016.02.001 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 97-102. Abstract Previous research demonstrated that human tear is a valuable source for biomarker discovery for many ocular surface diseases. Here, we systematically summarized the changes of tear protein profile in many ocular surface diseases, including dry eye, blepharitis, ocular allergy, […]

Dysfunction of tear film and ultrastructural changes of corneal epithelial cells in castrated male mice

Authors: Li Li,  Wang Shuangmei,  Zheng Xuan,  Kang Qianyan DOI: 10.3760/cma.j.issn.2095-0160.2016.02.002 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 103-107. Abstract Background Studies indicate that the decline of androgen level affects the secretion function of epithelial cells of meibomian glands and lacrimal glands, which results in the abnormality of tear quality and quantity. However, whether androgen level regulates […]

Protective effects of thymosin β4 on ethanol-induced rabbit corneal epithelial cell damage in vitro

Authors: Jiang Zhixin,  Hao Peng,  Tang Xin,  Li Xuan DOI: 10.3760/cma.j.issn.2095-0160.2016.02.003 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 108-114. Abstract Background Laser assisted subepithelial keratomileusis (LASEK) is one of surgical procedures for refractive correction. Dilute alcohol that is used for the removal of epithelium during LASEK induces the apoptosis of corneal epithelial cells. Researches showed that thymosin […]

Inhibitory effect of miR-204 on corneal epithelial cell proliferation in vitro

Authors: Liang Rongxin,  Du Jinlin,  Huang Tao DOI: 10.3760/cma.j.issn.2095-0160.2016.02.005 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 116-120. Abstract Background As the main cellular constituent of corneal epithelium, corneal epithelial cells play critical roles in regulating and controlling the migration, proliferation and differentiation of cells during the repair of damage. MicroRNA (miRNA) is endogenously expressed small non-coding […]

Feasibility of bacterial cellulose membrane as biological scaffold for construction of tissue engineering corneal epithelium

Authors: Cao Jingjie,  Zhang Chen,  Zhao Shaozhen,  Wan Yizao,  Hu Da DOI: 10.3760/cma.j.issn.2095-0160.2016.02.006 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 121-124. Abstract Background Corneal transplantation is a primary method for the treatment of serious corneal diseases, but its application is limited because of the shortage of corneal donor. The study on tissue engineering corneal epithelium provides a new […]

Pathogenesis and treatment of overwhelming inflammation induced by Pseudomonas aeruginosa keratitis in rabbit

Authors: Liang Qingfeng,  Li Bin,  Zhang Yang,  Labbe Antoine DOI: 10.3760/cma.j.issn.2095-0160.2016.02.007 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 125-131. Abstract Background Infectious keratitis is common blinding eye disease in China. Inflammatory runaway reaction often occurs in infectious keratitis, and its mechanism and treating approach are worthy of research. Objective This study was to investigate the clinical manifestation, […]

Isolation and culture of corneal neovascular endothelial cells and expression of chemokine receptors

Authors: Liu Gaoqin,  Xiao Yanhui,  Chen Zhigang,  Xu Jing,  Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2016.02.008 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 132-136. Abstract Background The pathogenesis and mechanism research of corneal neovascularization is of important significance for the prevention and management of corneal neovascularization. Some relative researches are being performed on non-corneal neovascularization-derived vascular endothelial cells, so the results […]

Clinical evaluation of Toric phakic posterior chamber intraocular collamer lens implantation for ametropia following deep anterior lamellar keratoplasty for keratoconus

Authors: Qin Qin,  Chen Hui,  Li Yizhuang,  Bao Lianyun DOI: 10.3760/cma.j.issn.2095-0160.2016.02.009 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 137-142. Abstract Background Postoperative ametropia, especially large astigmatism after deep anterior lamellar keratoplasty (DALK) for keratoconus often results in poor visual acuity. Though postoperative ametropia can be corrected by wearing glasses or performing corneal refractive surgery, the visual quality […]

Clinical effect of bioengineered cornea and in vivo confocal microscopy observation after human lamellar keraplasty

Authors: Wang Sujuan,  Zhang Yueqin,  Li Jin,  Yu Xiaofei,  Dou Xinyan,  Wang Liya DOI: 10.3760/cma.j.issn.2095-0160.2016.02.011 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 144-149. Abstract Background Xenotransplantation is arousing more attention of researchers because of the lack of corneal donors. Biological corneal scaffolds constructed by porcine corneal acellular stroma appears to have an acceptable biocompatibility. However, its clinical effects and […]

Comparation and analysis of therapeutic effect of penetrating keratoplasty for severe infectious keratitis caused by different pathogens

Authors: Peng Xudong,  Zhao Guiqiu,  Li Jianen,  Lin Jing,  Hu Liting,  Jiang Nan,  Wang Qian,  Qu Jianqiu,  Wang Xiaochuan DOI: 10.3760/cma.j.issn.2095-0160.2016.02.012 Published 2016-02-10 Cite as Chin J Exp Ophthalmol, 2016,34(2): 150-154. Abstract Background Refractory infectious keratitis is one of the leading causes of corneal blindness. Penetrating keratoplasty (PKP) is a primary approach to serious infectious keratitis patients who did not feasible to drug therapy. […]