Research progress of cellular senescence and senescence-associated secretory phenotype in eye diseases

2026，No. 05, Current Issue, Highlights, Review
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Authors: Lin Hongzhan, Yang Mingming
DOI: 10.3760/cma.j.cn115989-20231205-00197
  

Citation

Lin Hongzhan, Yang Mingming. Research progress of cellular senescence and senescence-associated secretory phenotype in eye diseases[J]. Chin J Exp Ophthalmol, 2026, 44(4):416-421. DOI: 10.3760/cma.j.cn115989-20231205-00197.

ABSTRACT                   [Download PDF]  [Read Full Text]

Cellular senescence is an irreversible cell cycle arrest induced by various stimuli such as oxidative stress, ischemia-reperfusion, and DNA damage. Recent studies have confirmed a close association between cellular senescence and the pathogenesis of various blinding eye diseases. Concurrent with cellular senescence, the expression of the senescence-associated secretory phenotype (SASP) influences the microenvironment of surrounding tissues, accelerating changes in ocular structure and function through the secretion of inflammatory cytokines, growth factors, chemokines, and other cellular factors. This article systematically elucidates the mechanisms and biological effects of senescent cell SASP, the correlation between SASP and the occurrence and development of various ocular diseases, and the therapeutic potential of SASP inhibitors/anti-aging drugs.

KEYWORDS：

Aging; Cellular senescence; Senescence-associated secretory phenotype; Eye diseases;Anti-aging cell drugs

Authors Info & Affiliations

Lin Hongzhan
Department of Ophthalmology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518020, China
Yang Mingming
Department of Ophthalmology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518020, China
Department of Ophthalmology, Shenzhen People’s Hospital (The First Affiliated Hospital, Southem University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen 518020, China
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