Research progress of purinergic signaling in dry age-related macular degeneration

Authors: Hu Yifan,  Sun Xiaodong
DOI: 10.3760/cma.j.cn115989-20190717-00316
Published 2022-01-10
Cite asChin J Exp Ophthalmol, 2022, 40(1): 78-82.
Abstract

Age-related macular degeneration (AMD) is one of the major causes of visual loss in people over 65 years of age. There is limited treatment for dry AMD, because of its complex mechanism. Purinergic signaling has the functions of signal transduction and neuro-modulation, participates in the development of dry AMD by regulating retinal cell death, microglial activity, inflammation, pathological deposit formation and retinal edema etc. In this study, we discussed the role and mechanisms involved in dry AMD by introducing the components of the purinergic signaling pathway, and further summarized the regulation of key processes in the pathogenesis of AMD in order to provide a reference for clinical research.

Key words:

Macular degeneration; Purinergic receptors; Review

Contributor Information

Hu Yifan

Department of Ophthalmology, The General Hospital of Shanghai, Shanghai JiaoTong University, Shanghai 200080, China

Sun Xiaodong

Department of Ophthalmology, The General Hospital of Shanghai, Shanghai JiaoTong University, Shanghai 200080, China

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